Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 19/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 19/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935241 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL1053723 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL935242 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL1060080 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL1060651 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL935183 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL934952 | 0.89 | SLC6A2 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL1057761 | 0.88 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL935706 | 0.88 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL934108 | 0.88 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454234-B1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2018-04-11 | — | — | EP | disclosed |
| CN-105254552-A | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE INC | 2016-01-20 | — | — | CN | disclosed |
| US-9227933-B2 | 3-phenoxymethylpyrrolidine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-01-05 | — | — | US | disclosed |
| US-20150126577-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-05-07 | — | — | US | disclosed |
| US-20110257243-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-7994209-B2 | 3-phenoxymethylpyrrolidine compounds | THERAVANCE, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-20110009465-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126577-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | SLC6A4 2/4885SLC6A2 3/4885SLC6A3 6/4885 |
| US-20110009465-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | SLC6A4 2/4885SLC6A2 3/4885SLC6A3 6/4885 |
| US-20110257243-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | SLC6A4 2/4885SLC6A2 3/4885SLC6A3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.