Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| M-Xylene SCHEMBL10601019 | 0.89 | KMT2A (0.46) | KMT2ARAB9ANR4A2TSHRACHE | |
| O-Xylene SCHEMBL27464940 | 0.88 | NR4A2 (0.45) | KMT2ARAB9ANR4A2LMNATSHR | |
| Succinic Acid SCHEMBL6574726 | 0.87 | KMT2A (0.61) | KMT2ARAB9ANR4A2LMNATSHR | |
| Succinic Acid SCHEMBL23045112 | 0.87 | KMT2A (0.61) | KMT2ARAB9ANR4A2LMNATSHR | |
| P-Cresol SCHEMBL10676708 | 0.85 | KMT2A (0.52) | KMT2ARAB9AACHEALDH1A1L3MBTL1 | |
| Biphenyl SCHEMBL28382562 | 0.83 | FFAR1 (0.57) | RAB9ANR4A2LMNATSHRALDH1A1 | |
| SCHEMBL10503491 | 0.83 | KMT2A (0.50) | KMT2ARAB9ALMNATSHRALDH1A1 | |
| SCHEMBL10598086 | 0.80 | KDM4E (0.41) | NR4A2TSHRALDH1A1GAAFFAR1 | |
| Fluorobenzene SCHEMBL10599852 | 0.80 | NR4A2 (0.45) | RAB9ANR4A2LMNATSHRALDH1A1 | |
| Chlorobenzene SCHEMBL10599624 | 0.80 | NR4A2 (0.45) | KMT2ARAB9ANR4A2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115133-B1 | SPIRO-3-HETERO-AZOLONES FOR TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4556670-A | Spiro-3-hetero-azolones for treatment of diabetic complications | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0115133-A1 | Spiro-3-hetero-azolones for treatment of diabetic complications | PFIZER INC. (US) | 1984-08-08 | — | — | EP | disclosed |