Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 10/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30346069 | 1.00 | ACHE (0.62) | ACHEPARP1PARP10STAT3MAOB | |
| SCHEMBL15153883 | 0.86 | ACHE (0.49) | ACHESTAT3MAOBNOS3SRD5A1 | |
| SCHEMBL12433394 | 0.80 | ACHE (0.61) | ACHEPARP1PARP10STAT3MAOB | |
| SCHEMBL24897684 | 0.79 | ACHE (0.53) | ACHEPARP1PARP10NOS3SRD5A1 | |
| SCHEMBL30917890 | 0.79 | PBRM1 (0.53) | ACHEPARP1PARP10STAT3SRD5A1 | |
| SCHEMBL24897762 | 0.79 | GRM5 (0.45) | ACHEPARP1PARP10STAT3SRD5A1 | |
| SCHEMBL1699469 | 0.79 | PBRM1 (0.53) | ACHEPARP1PARP10STAT3SRD5A1 | |
| SCHEMBL13534180 | 0.77 | ACHE (0.48) | ACHESRD5A1 | |
| SCHEMBL8254380 | 0.77 | STAT3 (0.42) | ACHESTAT3 | |
| SCHEMBL2585275 | 0.76 | ACHE (1.00) | ACHEPARP1PARP10NOS3SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115133-B1 | SPIRO-3-HETERO-AZOLONES FOR TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4556670-A | Spiro-3-hetero-azolones for treatment of diabetic complications | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0115133-A1 | Spiro-3-hetero-azolones for treatment of diabetic complications | PFIZER INC. (US) | 1984-08-08 | — | — | EP | disclosed |