Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8971352 | 0.90 | SMN1; SMN2 (0.42) | ACESMN1; SMN2ABCB11LMNA | |
| SCHEMBL8971348 | 0.90 | SMN1; SMN2 (0.42) | ACESMN1; SMN2ABCB11LMNA | |
| SCHEMBL11102007 | 0.89 | SMN1; SMN2 (0.41) | ACESMN1; SMN2ABCB11LMNA | |
| SCHEMBL6656395 | 0.84 | SMN1; SMN2 (0.44) | ACESMN1; SMN2ABCB11CTSSCTSK | |
| SCHEMBL6656396 | 0.84 | SMN1; SMN2 (0.44) | ACESMN1; SMN2ABCB11CTSSCTSK | |
| SCHEMBL10601120 | 0.84 | ACE (0.34) | ACESMN1; SMN2ABCB11CTSSCTSK | |
| SCHEMBL8972536 | 0.80 | ACE (0.46) | ACEABCB11LMNA | |
| SCHEMBL10602826 | 0.79 | ACE (0.37) | ACEABCB11 | |
| SCHEMBL11001187 | 0.79 | ACE (0.41) | ACESMN1; SMN2ABCB11LMNA | |
| SCHEMBL1994862 | 0.78 | SMN1; SMN2 (0.44) | ACESMN1; SMN2ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112511-B1 | NEW COMPOUNDS, PHARMACEUTICAL PREPARATIONS CONTAINING SAME AND PROCESS FOR THEIR PREPARATION | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-09-06 | — | — | EP | disclosed |
| US-4659711-A | 1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension | USV PHARMACEUTICAL CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |
| US-4596791-A | Containing heterocyclic fused ring | USV PHARMACEUTICAL CORP. (US) | 1986-06-24 | — | — | US | disclosed |
| US-4558038-A | HYPOTENSIVE AGENTS | USV PHARMACEUTICAL CORP. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4496542-A | HYPOTENSIVE AGENTS; ENZYME INHIBITORS | USV PHARMACEUTICAL CORPORATION (US) | 1985-01-29 | — | — | US | disclosed |
| US-4482544-A | Compounds for treating hypertension | USV PHARMACEUTICAL CORPORATION (US) | 1984-11-13 | — | — | US | disclosed |
| EP-0112511-A2 | New compounds, pharmaceutical preparations containing same and process for their preparation | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-07-04 | — | — | EP | disclosed |