Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 17/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11001187 | 0.86 | ACE (0.41) | ACEABCB11LMNA | |
| SCHEMBL8971352 | 0.81 | SMN1; SMN2 (0.42) | ACEABCB11LMNA | |
| SCHEMBL8971348 | 0.81 | SMN1; SMN2 (0.42) | ACEABCB11LMNA | |
| SCHEMBL11102007 | 0.80 | SMN1; SMN2 (0.41) | ACEABCB11LMNA | |
| SCHEMBL10602182 | 0.80 | ACE (0.40) | ACEABCB11LMNA | |
| SCHEMBL8972089 | 0.76 | ACE (0.73) | ACEABCB11PDE3ALMNA | |
| SCHEMBL8972073 | 0.73 | CA1 (0.36) | ACE | |
| SCHEMBL10601120 | 0.71 | ACE (0.34) | ACEABCB11LMNA | |
| SCHEMBL6656395 | 0.70 | SMN1; SMN2 (0.44) | ACEABCB11LMNA | |
| SCHEMBL6656396 | 0.70 | SMN1; SMN2 (0.44) | ACEABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175266-B1 | Antihypertensive derivatives | RHONE POULENC RORER PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4749698-A | Antihypertensive derivatives | RORER PHARMACEUTICAL CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
| US-4746676-A | Carboxyalkyl dipeptide compounds | RORER PHARMACEUTICAL CORPORATION (US) | 1988-05-24 | — | — | US | disclosed |
| EP-0175266-A2 | Antihypertensive derivatives | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4555508-A | Antihypertensive spiro-cyclic compounds | USV PHARMACEUTICAL CORP. (US) | 1985-11-26 | — | — | US | disclosed |