Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 3/20 | 0.55 |
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | BACE1 | P56817 | 3/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10610517 | 0.99 | SMN1; SMN2 (0.60) | HRH3GAASMN1; SMN2BCHEACHE | |
| Hydrochloric Acid SCHEMBL10668432 | 0.90 | SMN1; SMN2 (0.70) | HRH3GAASMN1; SMN2BCHEACHE | |
| SCHEMBL10607825 | 0.90 | HRH3 (0.62) | HRH3GAASMN1; SMN2BCHEACHE | |
| SCHEMBL10607203 | 0.87 | HRH3 (0.60) | HRH3GAASMN1; SMN2BCHEACHE | |
| Hydrochloric Acid SCHEMBL10608924 | 0.86 | GAA (0.61) | HRH3GAASMN1; SMN2BCHEACHE | |
| SCHEMBL13450917 | 0.86 | GAA (0.61) | HRH3GAASMN1; SMN2BCHEACHE | |
| SCHEMBL10608375 | 0.86 | SIGMAR1 (0.61) | HRH3GAASMN1; SMN2ACHEBACE1 | |
| SCHEMBL10608592 | 0.86 | HRH3 (0.59) | HRH3GAASMN1; SMN2BCHEACHE | |
| SCHEMBL13450402 | 0.86 | GAA (0.61) | HRH3GAASMN1; SMN2BCHEACHE | |
| SCHEMBL10605546 | 0.85 | BCHE (0.58) | HRH3GAASMN1; SMN2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147909-B1 | ARYLOXY-N-(AMINOALKYL)-1-PYRROLIDINE AND PIPERIDINE CARBOXAMIDES AND CARBOTHIOAMIDES HAVING ANTIARRHYTHMIC ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4547514-A | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-10-15 | — | — | US | disclosed |
| EP-0147909-A1 | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |