Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | PPOX | P50336 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10606341 | 0.88 | TDP1 (0.69) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10604884 | 0.84 | MEN1 (0.67) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10604953 | 0.80 | MEN1 (0.49) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10603239 | 0.80 | MEN1 (0.66) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10608534 | 0.77 | MEN1 (0.54) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10603393 | 0.76 | MEN1 (0.69) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10822223 | 0.74 | MEN1 (0.48) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10606203 | 0.74 | FFAR1 (0.46) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10788544 | 0.73 | TDP1 (0.60) | TDP1MERTKMEN1KMT2ATTR | |
| Bifenox SCHEMBL7587174 | 0.71 | TDP1 (0.75) | TDP1MERTKMEN1KMT2ATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167349-B1 | META-SUBSTITUTED DIOXA-ALKANE CARBOXYLIC ACIDS, ESTERS, AMIDES AND SALTS OF DIPHENYL ETHERS | ROHM AND HAAS COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| EP-0167349-A2 | Meta-substituted dioxa-alkane carboxylic acids, esters, amides and salts of diphenyl ethers | ROHM AND HAAS COMPANY (US) | 1986-01-08 | — | — | EP | disclosed |