Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30477 | 0.95 | TSHR (0.36) | TSHRDNM1 | |
| Bromide SCHEMBL302580 | 0.95 | TSHR (0.36) | TSHRDNM1 | |
| SCHEMBL29563566 | 0.89 | — | — | |
| SCHEMBL9752174 | 0.84 | TSHR (0.36) | TSHR | |
| Hydrochloric Acid SCHEMBL127178 | 0.84 | TSHR (0.36) | TSHR | |
| Fluoride Ion SCHEMBL941760 | 0.84 | TSHR (0.36) | TSHR | |
| Iodide SCHEMBL3863164 | 0.84 | TSHR (0.38) | TSHR | |
| Water SCHEMBL107107 | 0.84 | TSHR (0.36) | TSHR | |
| SCHEMBL7178147 | 0.84 | — | — | |
| SCHEMBL2862407 | 0.80 | TSHR (0.33) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208265-B1 | 1-Oxa-3,8-diaza-4-oxo-spiro[4,5]decane compounds and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-23 | — | — | EP | disclosed |