Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063952 | 0.99 | HDAC1 (0.58) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL16011052 | 0.90 | HDAC4 (0.60) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1065607 | 0.89 | HDAC1 (0.61) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL16011100 | 0.87 | HDAC4 (0.63) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1062300 | 0.84 | HDAC8 (0.62) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1063975 | 0.83 | HDAC8 (0.60) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1064490 | 0.82 | HDAC8 (0.56) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL16010906 | 0.82 | HDAC3 (0.52) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1063215 | 0.82 | HDAC3 (0.55) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL16010979 | 0.81 | HDAC4 (0.66) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957225-B2 | Treatment of friedreich's ataxia using histone deacetylase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-01 | — | — | US | disclosed |
| US-20150080472-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE | 2015-03-19 | — | — | US | disclosed |
| US-8835502-B2 | Treatment of friedreich's ataxia using histone deacetylase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-09-16 | — | — | US | disclosed |
| US-20130210918-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-08-15 | — | — | US | disclosed |
| US-20110021562-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | THE SCRIPPS RESEARCH INSTUTE (US) | 2011-01-27 | — | — | US | disclosed |
| US-20070219244-A1 | Histone deacetylase inhibitors as therapeutics for neurological diseases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021562-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC4, HDAC6 | HDAC1 1/4885HDAC8 8/4885HDAC6 3/4885 |
| US-20130210918-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC4, HDAC6 | HDAC1 1/4885HDAC8 8/4885HDAC6 3/4885 |
| US-20150080472-A1 | TREATMENT OF FRIEDREICH'S ATAXIA USING HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC4, HDAC6 | HDAC1 1/4885HDAC8 8/4885HDAC6 3/4885 |
| US-20070219244-A1 | Histone deacetylase inhibitors as therapeutics for neurological diseases | HDAC5, HDAC1, HDAC6 | HDAC1 2/4885HDAC8 10/4885HDAC6 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.