SCHEMBL10608166

SCHEMBL10608166

CC(C(=O)OC12CC3CC(CC(C3)C1)C2)c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 1/20 0.56
CYP19A1 P11511 1/20 0.56
ALDH1A1 P00352 3/20 0.50
NPSR1 Q6W5P4 1/20 0.50
KMT2A Q03164 3/20 0.49
GAA P10253 4/20 0.46
MAPT P10636 1/20 0.44
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.40
TP53 P04637 1/20 0.40
SLC6A3 Q01959 1/20 0.40
EPHX2 P34913 1/20 0.39
HTR2A P28223 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10608522 0.81 CYP19A1 (0.61) CYP17A1CYP19A1ALDH1A1SLC6A3
SCHEMBL6363107 0.77 PTPN2 (0.50) ALDH1A1KMT2ARAB9ANPC1
SCHEMBL10608194 0.76 KMT2A (0.47) ALDH1A1KMT2AGAAMAPTRAB9A
SCHEMBL24727719 0.76 ALDH1A1 (0.48) ALDH1A1NPSR1KMT2AGAAMAPT
SCHEMBL5278099 0.76 ALDH1A1 (0.42) CYP17A1CYP19A1ALDH1A1NPSR1KMT2A
SCHEMBL1345434 0.74 KMT2A (0.56) KMT2AGAAMAPTRAB9ATP53
SCHEMBL1345244 0.74 KMT2A (0.56) KMT2AGAAMAPTRAB9ATP53
SCHEMBL427393 0.74 KMT2A (0.56) KMT2AGAAMAPTRAB9ATP53
SCHEMBL12745733 0.74 ALDH1A1 (0.55) ALDH1A1NPSR1KMT2AGAAMAPT
SCHEMBL4136472 0.72 ALDH1A1 (0.58) ALDH1A1KMT2AGAAMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4762840-A ANTIASTHMA, BRONCHITIS ROUSSEL UCLAF (FR) 1988-08-09 US disclosed