Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28333937 | 0.98 | HDAC8 (0.54) | HDAC8CYP2A6ALDH1A1TSHRHSD17B10 | |
| Bromide SCHEMBL8663821 | 0.88 | KMT2A (0.48) | HDAC8CYP2A6TSHRHSD17B10MAPT | |
| SCHEMBL8660074 | 0.85 | KMT2A (0.50) | HDAC8CYP2A6TSHRHSD17B10MAPT | |
| Bromide SCHEMBL5489286 | 0.84 | KMT2A (0.60) | TSHRHSD17B10MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11600265 | 0.83 | MEN1 (0.48) | HDAC8CYP2A6TSHRHSD17B10MAPT | |
| Bromide SCHEMBL8425884 | 0.82 | HDAC8 (0.50) | HDAC8CYP2A6BCHEACHE | |
| SCHEMBL28336347 | 0.82 | HDAC8 (0.56) | HDAC8CYP2A6ALDH1A1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL8775080 | 0.80 | KMT2A (0.60) | TSHRMAPTMEN1KMT2ATP53 | |
| Bromide SCHEMBL8428013 | 0.80 | HDAC8 (0.48) | HDAC8BCHEACHE | |
| Iodide SCHEMBL10672612 | 0.80 | HDAC8 (0.54) | HDAC8CYP2A6ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4756845-A | Peroxide, cyanopyridine activator, cyanopyridinium salt | LION CORPORATION (JP) | 1988-07-12 | — | — | US | disclosed |