Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Trichloroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250080 | 0.78 | SIGMAR1 (0.91) | SIGMAR1EPHX1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL2740865 | 0.72 | SIGMAR1 (0.72) | SIGMAR1EPHX1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL7623949 | 0.72 | SIGMAR1 (0.71) | SIGMAR1EPHX1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL7623945 | 0.72 | SIGMAR1 (0.71) | SIGMAR1EPHX1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL6154078 | 0.71 | SIGMAR1 (0.70) | SIGMAR1EPHX1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL6155365 | 0.70 | SIGMAR1 (0.76) | SIGMAR1EPHX1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL3080580 | 0.69 | SIGMAR1 (0.61) | SIGMAR1EPHX1NPC1SMN1; SMN2RAB9A | |
| Trichloroacetic Acid SCHEMBL9636957 | 0.69 | SIGMAR1 (0.34) | SIGMAR1ALDH1A1KDM4E | |
| Trichloroacetic Acid SCHEMBL9636965 | 0.69 | SIGMAR1 (0.34) | SIGMAR1ALDH1A1KDM4E | |
| Trichloroacetic Acid SCHEMBL9636962 | 0.69 | EPHX1 (0.40) | EPHX1NPC1SMN1; SMN2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4749679-A | Heat sensitive recording materials | FUJI PHOTO FILM CO., LTD. (JP) | 1988-06-07 | — | — | US | disclosed |