Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18484139 | 0.80 | PTPN11 (0.43) | TSHRKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12490953 | 0.80 | PTPN11 (0.43) | TSHRKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3161270 | 0.79 | ALDH1A1 (0.56) | CYP3A4CYP2D6TSHRMEN1KMT2A | |
| SCHEMBL23593463 | 0.79 | PTPN11 (0.48) | TSHRKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8297011 | 0.78 | ALDH1A1 (0.46) | TSHRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12491029 | 0.76 | PIK3CA (0.41) | TSHRKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2557704 | 0.76 | PTPN11 (0.44) | TSHRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12572057 | 0.75 | ALDH1A1 (0.52) | TSHRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8297012 | 0.75 | ALDH1A1 (0.46) | CYP3A4TSHRMEN1KMT2AKDM4E | |
| SCHEMBL8298031 | 0.75 | ALDH1A1 (0.46) | TSHRMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4751305-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-14 | — | — | US | disclosed |
| US-4748246-A | INTERLEUKIN ANTAGONISTS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |