SCHEMBL10614735

SCHEMBL10614735

O=P(O)(S)Oc1cccc(Cl)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 1/20 0.43
INPPL1 O15357 1/20 0.41
INPP5B P32019 1/20 0.41
INPP5A Q14642 1/20 0.41
SFN P31947 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.38
TSHR P16473 3/20 0.38
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
PTK2B Q14289 1/20 0.37
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
RHEB Q15382 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL557291 0.85 INPPL1 (0.59) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL29114274 0.83 SMN1; SMN2 (0.44) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL5441328 0.80 SMN1; SMN2 (0.48) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL29114276 0.80 SMN1; SMN2 (0.42) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL10353862 0.79 SMN1; SMN2 (0.47) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL3906733 0.79 SMN1; SMN2 (0.47) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL9643709 0.77 RHEB (0.41) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL11586181 0.76 SRC (0.47) SMN1; SMN2LMNASFNPTK2BPOLB
SCHEMBL9622381 0.76 POLB (0.43) SMN1; SMN2LMNAINPPL1INPP5BINPP5A
SCHEMBL28458158 0.76 SMN1; SMN2 (0.44) SMN1; SMN2LMNAINPPL1INPP5BINPP5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-63301803-A None JP disclosed
JP-S63301803-A TERMITE-PROOFING AGENT AND WOOD INSECTICIDE NIPPON CHEM IND CO LTD:THE 1988-12-08 JP disclosed