SCHEMBL10619331

SCHEMBL10619331

O=C(c1ccc(O)c(Cl)c1)c1ccccc1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.46
RORC P51449 2/20 0.46
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
HSD17B1 P14061 3/20 0.43
HSD17B2 P37059 3/20 0.43
CNR2 P34972 2/20 0.43
STK10 O94804 1/20 0.42
SLK Q9H2G2 1/20 0.42
MAPK14 Q16539 1/20 0.42
LTC4S Q16873 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
KCNK3 O14649 1/20 0.41
KCNK9 Q9NPC2 1/20 0.41
MGLL Q99685 1/20 0.41
HSP90AA1 P07900 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10620811 0.85 SMN1; SMN2 (0.48) SMN1; SMN2RORCALDH1A1POLBLMNA
SCHEMBL15100878 0.84 SMN1; SMN2 (0.48) SMN1; SMN2RORCALDH1A1POLBLMNA
SCHEMBL10428298 0.81 SMN1; SMN2 (0.51) SMN1; SMN2ALDH1A1POLBLMNAGAA
SCHEMBL10623559 0.81 HSD17B1 (0.45) RORCALDH1A1POLBHSD17B1HSD17B2
SCHEMBL10623624 0.81 KMT2A (0.51) SMN1; SMN2RORCALDH1A1LMNAGAA
SCHEMBL10621479 0.80 SMN1; SMN2 (0.47) SMN1; SMN2RORCALDH1A1LMNAGAA
SCHEMBL10621547 0.80 SMN1; SMN2 (0.59) SMN1; SMN2RORCALDH1A1POLBLMNA
SCHEMBL10621430 0.79 SMN1; SMN2 (0.46) SMN1; SMN2RORCALDH1A1POLBLMNA
Potassium Ion SCHEMBL10620963 0.79 SMN1; SMN2 (0.46) SMN1; SMN2RORCALDH1A1POLBLMNA
SCHEMBL7365546 0.79 SLC22A6 (0.60) SMN1; SMN2ALDH1A1LMNAGAAHSD17B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0118661-B1 FLUORINE-CONTAINING BENZOPHENONE DERIVATIVES Daikin Kogyo Co., Ltd. (JP) 1988-04-13 EP disclosed
US-4622066-A HERBICIDES DAIKIN KOGYO CO., LTD. (JP) 1986-11-11 US disclosed
EP-0118661-A2 Fluorine-containing benzophenone derivatives Daikin Kogyo Co., Ltd. (JP) 1984-09-19 EP disclosed