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Sugi Predict / Targets / HSD17B1

HSD17B1

17-beta-hydroxysteroid dehydrogenase type 1 · P14061 · HSD17B1 on Sugi Atlas →

91,829 patent compounds predicted against HSD17B1, 46,449 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL21915 SCHEMBL21915 1.00 20/20
SCHEMBL21944 SCHEMBL21944 1.00 20/20
SCHEMBL22378 SCHEMBL22378 1.00 20/20
SCHEMBL22496 SCHEMBL22496 1.00 20/20
SCHEMBL22898 SCHEMBL22898 1.00 20/20
SCHEMBL23023 SCHEMBL23023 1.00 20/20
SCHEMBL23374 SCHEMBL23374 1.00 20/20
SCHEMBL23418 SCHEMBL23418 1.00 20/20
SCHEMBL23686 SCHEMBL23686 1.00 20/20
SCHEMBL24263 SCHEMBL24263 1.00 20/20
SCHEMBL24752 SCHEMBL24752 1.00 20/20
SCHEMBL30431 SCHEMBL30431 1.00 20/20
SCHEMBL30683 SCHEMBL30683 1.00 20/20
SCHEMBL31120 SCHEMBL31120 1.00 20/20
SCHEMBL31128 SCHEMBL31128 1.00 20/20
SCHEMBL31406 SCHEMBL31406 1.00 20/20
SCHEMBL22550 SCHEMBL22550 0.88 20/20
SCHEMBL23522 SCHEMBL23522 0.84 20/20
SCHEMBL31075 SCHEMBL31075 0.82 20/20
SCHEMBL22914 SCHEMBL22914 0.78 20/20

Clinical trials — most relevant to HSD17B1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment PHASE4RECRUITING
Abiraterone Acetate in Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy PHASE3COMPLETED
Testosterone Treatment in a Patient With 17β-hydroxysteroid Dehydrogenase Type 3 Deficiency: an N-of-1 Study PHASE3UNKNOWN
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS) PHASE3COMPLETED
The Role of Mineralocorticoid Receptors in Vascular Function PHASE2/PHASE3COMPLETED
Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia PHASE1/PHASE2COMPLETED
Androgen Reduction in Congenital Adrenal Hyperplasia PHASE2WITHDRAWN
Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma PHASE2UNKNOWN
AMG 386 and Abiraterone for Advanced Prostate Cancer PHASE2COMPLETED
Study of SPR001 in Adults With Classic Congenital Adrenal Hyperplasia PHASE2COMPLETED
Glucocorticoids and Skin Healing in Diabetes (GC-SHealD) PHASE2COMPLETED
A Study Examining Doses of Abiraterone Acetate in Adult Women With 21-Hydroxylase Deficiency PHASE1COMPLETED
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole nanWITHDRAWN
Mutation Analysis of 17βhydroxysteroid Dehydrogenase 3 Deficiency nanUNKNOWN
Linear Growth of Children With Congenital Adrenal Hyperplasia nanUNKNOWN
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Determining the Long-Term Effects of Prenatal Dexamethasone Treatment in Children With 21-Hydroxylase Deficiency and Their Mothers nanUNKNOWN
Final Height in Patients With CAH nanUNKNOWN
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency nanCOMPLETED
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS) nanCOMPLETED
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome nanCOMPLETED
Exercise Capacity, Physical Fitness, and Physical Activity Levels in Children With CAH nanCOMPLETED
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas nanUNKNOWN
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes nanNOT_YET_RECRUITING
Adrenal Function in GHD Children nanCOMPLETED
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension nanUNKNOWN
Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency. nanUNKNOWN
Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS) nanCOMPLETED
Fertility and Pregnancy in Patients With Classic Congenital Adrenal Hyperplasia nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HSD17B1 binder may also engage these)

ProteinNameSimilarity
Q1WNP0 — 1.000 Q1WNP0 →
P51657 — 0.993 P51657 →
P51656 — 0.979 P51656 →
P55203 — 0.978 P55203 →
A0AAT9JA24 — 0.976 A0AAT9JA24 →
Q9NYR8 — 0.974 Q9NYR8 →
P52785 — 0.974 P52785 →
P51661 — 0.971 P51661 →
EPHB4 Ephrin type-B receptor 4 0.971 landscape →
HSD11B2 11-beta-hydroxysteroid dehydrogenase type 2 0.970 landscape →
Q6ZPS2 — 0.969 Q6ZPS2 →
Q571I9 — 0.969 Q571I9 →
P0DPD7 — 0.969 P0DPD7 →
O55230 — 0.969 O55230 →
Q7ZY31 — 0.969 Q7ZY31 →
Q08DH8 — 0.969 Q08DH8 →
Q96KV7 — 0.968 Q96KV7 →
ULK3 Serine/threonine-protein kinase ULK3 0.968 landscape →
P51840 — 0.968 P51840 →
PAOX Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 0.968 landscape →
Q96EY9 — 0.968 Q96EY9 →
Q9N126 — 0.968 Q9N126 →
Q9H2F3 — 0.968 Q9H2F3 →
O55171 — 0.967 O55171 →
Q8CGS5 — 0.967 Q8CGS5 →
Q643R3 — 0.967 Q643R3 →
Q865R1 — 0.967 Q865R1 →
Q5R9W5 — 0.967 Q5R9W5 →
A6QR56 — 0.967 A6QR56 →
O43542 — 0.967 O43542 →