Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | NPM1 | P06748 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31625035 | 0.68 | CHEK1 (0.31) | ALKCHEK1AURKADAPK3JAK2 | |
| SCHEMBL13220859 | 0.67 | IDO1 (0.36) | IDO1 | |
| SCHEMBL24807017 | 0.66 | ALDH1A1 (0.36) | DYRK1ABRAFIDO1 | |
| SCHEMBL24378613 | 0.65 | PDE10A (0.44) | PDE10A | |
| SCHEMBL18378942 | 0.64 | IDO1 (0.51) | IDO1 | |
| SCHEMBL25120199 | 0.61 | IDO1 (0.39) | IDO1 | |
| SCHEMBL24171795 | 0.61 | PDE10A (0.40) | PDE10A | |
| SCHEMBL19534288 | 0.61 | IDO1 (0.39) | IDO1 | |
| SCHEMBL18378756 | 0.61 | IDO1 (0.42) | IDO1 | |
| SCHEMBL23143355 | 0.60 | ALK (0.42) | ALKNPM1CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0134928-B1 | Imidazo[1,5-a]pyrimidine derivatives and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1988-02-03 | — | — | EP | claimed |
| EP-0134928-B1 | Imidazo[1,5-a]pyrimidine derivatives and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1988-02-03 | — | — | EP | disclosed |