Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 16/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10623530 | 0.81 | SLC6A3 (0.91) | SLC6A3SLC6A4KCNH2SLC6A2 | |
| SCHEMBL13755345 | 0.81 | SLC6A4 (0.65) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 | |
| Hydrochloric Acid SCHEMBL2078 | 0.81 | KCNH2 (0.55) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 | |
| SCHEMBL9863766 | 0.80 | SLC6A3 (0.58) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 | |
| Hydrochloric Acid SCHEMBL2524 | 0.80 | KCNH2 (0.91) | SLC6A3SLC6A4KCNH2SLC6A2CYP3A4 | |
| SCHEMBL10899829 | 0.80 | SLC6A3 (0.58) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 | |
| SCHEMBL9863983 | 0.79 | SLC6A3 (0.57) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 | |
| Sibutramine SCHEMBL2672138 | 0.79 | SLC6A3 (1.00) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 | |
| Hydrochloric Acid SCHEMBL9864297 | 0.79 | CYP3A4 (0.59) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 | |
| Sibutramine SCHEMBL2955 | 0.79 | SLC6A3 (1.00) | SLC6A3SLC6A4KCNH2SLC6A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | claimed |
| US-9925202-B2 | Treatment of lymphangioleiomyomatosis | BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2018-03-27 | — | — | US | disclosed |