SLC6A3

Sodium-dependent dopamine transporter · Q01959 · SLC6A3 on Sugi Atlas →

783,926 patent compounds predicted against SLC6A3, 461,861 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL1375)	0.66	20/20
SCHEMBL2793	0.57	19/20
Hydrochloric Acid (SCHEMBL2049)	0.71	18/20
Hydrochloric Acid (SCHEMBL2314)	0.65	18/20
Hydrochloric Acid (SCHEMBL2616)	0.61	18/20
Hydrochloric Acid (SCHEMBL2448)	0.61	18/20
Hydrochloric Acid (SCHEMBL2287)	0.59	18/20
SCHEMBL2644	0.57	18/20
Hydrochloric Acid (SCHEMBL2105)	0.88	17/20
Hydrochloric Acid (SCHEMBL2216)	0.88	17/20
Hydrochloric Acid (SCHEMBL2283)	0.69	17/20
Hydrochloric Acid (SCHEMBL1903)	0.68	17/20
Hydrochloric Acid (SCHEMBL1864)	0.66	17/20
SCHEMBL2468	0.65	17/20
SCHEMBL2150	0.64	17/20
SCHEMBL1822	0.63	17/20
Hydrochloric Acid (SCHEMBL2082)	0.63	17/20
Hydrochloric Acid (SCHEMBL2666)	0.63	17/20
Hydrochloric Acid (SCHEMBL2541)	0.62	17/20
Hydrochloric Acid (SCHEMBL2241)	0.60	17/20

Clinical trials — most relevant to SLC6A3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)	PHASE4	COMPLETED
Strattera Treatment in Children With ADHD Who Have Poor Response to Stimulant Therapy	PHASE4	COMPLETED
Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities	PHASE3	COMPLETED
Effects of Antidepressant Therapy on Brain Dopamine Transporter Activity in People With Major Depression	PHASE2/PHASE3	COMPLETED
Aripiprazole Effects on Alcohol Drinking and Craving	PHASE3	COMPLETED
PET Imaging of Dopamine in Healthy Study Participants	PHASE2	COMPLETED
Low-dose vs. Normal-dose Psychostimulants on Executive Functions in Individuals With ADHD	PHASE1/PHASE2	UNKNOWN
Study to Identify Clinical, Imaging and Biologic Markers of Parkinson Disease Progression	PHASE2	COMPLETED
Modafinil vs Placebo for the Treatment of Methamphetamine Dependence	PHASE2	COMPLETED
Stimulant Effects on Brain Activity	PHASE1	COMPLETED
Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2	PHASE1	COMPLETED
Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1	PHASE1	COMPLETED
Influence of Bupropion on the Effects of MDMA	PHASE1	COMPLETED
Application of 18F-CP6A PET Imaging in Synucleinopathies	EARLY_PHASE1	NOT_YET_RECRUITING
Multimodal Neurobiological Approaches to Explore the Gene-Environment Interactions in ADHD	nan	COMPLETED
Neuroimaging of Dopamine Metabolism in Normal and Psychiatric Patients	nan	COMPLETED
A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.	nan	UNKNOWN
Pharmacogenetic Studies on Attention Deficit Hyperactivity Disorder	nan	COMPLETED
Stem Cell Study of Genetics and Drug Addiction	nan	COMPLETED
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI	nan	COMPLETED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI	nan	COMPLETED
Autonomic Function in Patients With COPD	nan	COMPLETED
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
The Genetic Basis for Vulnerability to Substance Abuse	nan	COMPLETED
Brain Stimulation and Attention Control in Children With ADHD	nan	ENROLLING_BY_INVITATION
Developing Genetic Education for Smoking Cessation	nan	COMPLETED
DaTSCAN Brain Scintigraphy and Psychotropic Treatments: Influence on Radiotracer Binding	nan	COMPLETED
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder	nan	UNKNOWN
I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC6A3 binder may also engage these)

Protein	Name	Similarity
P23977	—	1.000	P23977 →
Q61327	—	1.000	Q61327 →
Q9GJT6	—	1.000	Q9GJT6 →
SLC6A4	Sodium-dependent serotonin transporter	1.000	landscape →
P31649	—	1.000	P31649 →
O18875	—	1.000	O18875 →
P51143	—	1.000	P51143 →
Q9MYX0	—	1.000	Q9MYX0 →
P51905	—	1.000	P51905 →
P31652	—	1.000	P31652 →
P28570	—	1.000	P28570 →
P31661	—	1.000	P31661 →
P31646	—	1.000	P31646 →
Q9MZ34	—	1.000	Q9MZ34 →
P48029	—	1.000	P48029 →
Q8VBW1	—	1.000	Q8VBW1 →
SLC6A13	Sodium- and chloride-dependent GABA transporter 2	1.000	landscape →
O88575	—	1.000	O88575 →
B4JMC1	—	1.000	B4JMC1 →
P48057	—	1.000	P48057 →
Q03614	—	1.000	Q03614 →
Q00589	—	1.000	Q00589 →
Q9XT49	—	1.000	Q9XT49 →
Q7K4Y6	—	1.000	Q7K4Y6 →
P31651	—	0.999	P31651 →
SLC6A6	Sodium- and chloride-dependent taurine transporter	0.999	landscape →
SLC6A19	Sodium-dependent neutral amino acid transporter B(0)AT1	0.999	landscape →
SLC6A11	Sodium- and chloride-dependent GABA transporter 3	0.999	landscape →
Q9NP91	—	0.999	Q9NP91 →
O35316	—	0.999	O35316 →