Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.47 |
| ▸ | DRD1 | P21728 | 13/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | DRD5 | P21918 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10623780 | 0.94 | DRD2 (0.45) | DRD2DRD4HRH4DRD1MAPK1 | |
| SCHEMBL10620839 | 0.90 | DRD2 (0.45) | DRD2DRD4HRH4DRD1 | |
| SCHEMBL10620883 | 0.89 | DRD2 (0.39) | DRD2DRD4HRH4DRD1MAPK1 | |
| SCHEMBL10621376 | 0.88 | DRD2 (0.36) | DRD2DRD4HRH4DRD1MAPK1 | |
| SCHEMBL10623484 | 0.88 | DRD2 (0.36) | DRD2DRD4HRH4DRD1MAPK1 | |
| SCHEMBL10623795 | 0.88 | MEN1 (0.44) | DRD2DRD4HRH4DRD1MAPK1 | |
| SCHEMBL10620893 | 0.88 | HRH4 (0.50) | DRD2DRD4HRH4DRD1MAPK1 | |
| SCHEMBL10625744 | 0.88 | DRD2 (0.42) | DRD2DRD4HRH4DRD1ADRA2A | |
| SCHEMBL10620843 | 0.87 | DRD2 (0.64) | DRD2DRD4HRH4DRD1MAPK1 | |
| SCHEMBL10621494 | 0.87 | MAPK1 (0.58) | DRD2DRD4HRH4DRD1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761412-A | Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for the treatment of psychoses | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-02 | — | — | US | claimed |
| US-4663453-A | Benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepines having dopamine receptor activity | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-05-05 | — | — | US | claimed |
| US-4764616-A | ANALGESIC, ANTIPHYCHOTIC | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-16 | — | — | US | disclosed |
| US-4761412-A | Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for the treatment of psychoses | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4761411-A | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4723003-A | ANTIPSYCHOTIC AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4723007-A | ANALGESICS, ANTIPSYCHOTIC AGENTS; INTERMEDIATES FOR PROCESSING | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4663453-A | Benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepines having dopamine receptor activity | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0129692-A2 | Dibenzodiazepin derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-01-02 | — | — | EP | disclosed |