Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.68 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.68 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.68 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.68 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.68 |
| ▸ | GABRP | O00591 | 8/20 | 0.68 |
| ▸ | GABRD | O14764 | 8/20 | 0.68 |
| ▸ | GABRB1 | P18505 | 8/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.68 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.68 |
| ▸ | GABRE | P78334 | 8/20 | 0.68 |
| ▸ | GABRG1 | Q8N1C3 | 8/20 | 0.68 |
| ▸ | GABRG3 | Q99928 | 8/20 | 0.68 |
| ▸ | GABRQ | Q9UN88 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10416983 | 0.85 | GABRA1 (0.72) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10627426 | 0.84 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10627428 | 0.84 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10625009 | 0.84 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10625013 | 0.84 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10624978 | 0.83 | GABRA1 (0.69) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10768659 | 0.82 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8908666 | 0.82 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10835133 | 0.82 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10834788 | 0.81 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4757070-A | 3-oxadiazolyl-5-aminoalkyl-beta-carboline derivatives compositions and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-07-12 | — | — | US | disclosed |
| US-4731365-A | 5-aminoalkyl-beta-carboline derivatives, psycho tropic compositions and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-03-15 | — | — | US | disclosed |