Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 9/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10639055 | 0.84 | PDE3B (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10632401 | 0.79 | PDE3B (0.63) | PDE3BPDE3AKMT2APDE4APDE4B | |
| SCHEMBL2069470 | 0.77 | KMT2A (0.56) | KMT2AMAPTHSD17B10NUDT1ALDH1A1 | |
| SCHEMBL256096 | 0.77 | MAPT (0.56) | PDE3BPDE3AKMT2APOLBMAPT | |
| SCHEMBL10632774 | 0.77 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8268881 | 0.76 | KMT2A (0.68) | KMT2AMAPTHSD17B10NUDT1ALDH1A1 | |
| SCHEMBL13272035 | 0.76 | KMT2A (0.55) | KMT2AMAPTHSD17B10NUDT1ALDH1A1 | |
| SCHEMBL10635773 | 0.75 | MAPT (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10632795 | 0.74 | PDE3B (0.50) | PDE3BPDE3AKMT2APDE4APDE4B | |
| SCHEMBL10636277 | 0.74 | PDE3B (0.50) | PDE3BPDE3AKMT2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0118790-B1 | NOVEL AROYLIMIDAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4552880-A | Aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0118790-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-09-19 | — | — | EP | disclosed |