Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10925750 | 0.83 | MAPT (0.51) | MAPTHSD17B10POLBCYP1A2CYP2C9 | |
| Bromide SCHEMBL10926306 | 0.82 | MAPT (0.50) | MAPTHSD17B10POLBCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL10926845 | 0.82 | MAPT (0.50) | MAPTHSD17B10POLBCYP1A2CYP2C9 | |
| SCHEMBL10632401 | 0.81 | PDE3B (0.63) | MAPTHSD17B10POLBCYP1A2ALDH1A1 | |
| SCHEMBL3017686 | 0.81 | CYP1A2 (0.58) | MAPTHSD17B10CYP1A2CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL10924459 | 0.80 | MAPT (0.49) | MAPTHSD17B10POLBCYP1A2CYP2C9 | |
| Water SCHEMBL10922371 | 0.80 | MAPT (0.49) | MAPTHSD17B10POLBCYP1A2CYP2C9 | |
| SCHEMBL10924480 | 0.79 | MAPT (0.48) | MAPTHSD17B10POLBCYP1A2CYP2C9 | |
| SCHEMBL7342972 | 0.79 | PDE3B (0.45) | MAPTHSD17B10POLBPDE3BPDE3A | |
| SCHEMBL10635773 | 0.78 | MAPT (0.50) | MAPTHSD17B10POLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | BAYER CROPSCIENCE AG (DE) | 2012-06-21 | — | — | US | disclosed |
| WO-2012028578-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER CROPSCIENCE AG (DE) | 2012-03-08 | — | — | WO | disclosed |
| EP-0078545-B1 | IMIDAZOLECARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-02-03 | — | — | EP | disclosed |
| US-4418071-A | Cardiotonic imidazolecarboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-11-29 | — | — | US | disclosed |
| EP-0078545-A1 | Imidazolecarboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | DHPS, FDPS, DPYD | MAPT 3143/4885HSD17B10 1447/4885POLB 1513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.