Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | CDC25B | P30305 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10637943 | 0.78 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| SCHEMBL10633508 | 0.77 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| Anthraquinone SCHEMBL8669687 | 0.75 | CDC25B (0.75) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| SCHEMBL10633969 | 0.74 | ALDH1A1 (0.55) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| SCHEMBL10631230 | 0.74 | MAPT (0.44) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| SCHEMBL28489133 | 0.74 | TOP1 (0.47) | MAPTALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL1104624 | 0.73 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| SCHEMBL14431153 | 0.73 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| SCHEMBL12585064 | 0.72 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2HTTHIF1A | |
| SCHEMBL23095433 | 0.70 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4758561-A | N-substituted 2-aminomethylene-1,3-indanediones for treating arterial hypertension and spasmodic conditions | SOCIETE CORTIAL, S.A. (FR) | 1988-07-19 | — | — | US | disclosed |
| US-4757067-A | Therapeutic application of N-substituted 2-aminomethylene-1,3-indanediones | SOCIETE CORTIAL, S.A. (FR) | 1988-07-12 | — | — | US | disclosed |