Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPS1 | P31327 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10634871 | 0.90 | CPS1 (0.60) | CPS1NPC1RAB9APOLBHSD11B1 | |
| SCHEMBL10637442 | 0.81 | MEN1 (0.57) | ALDH1A1 | |
| SCHEMBL10637499 | 0.81 | NPC1 (0.57) | CPS1NPC1RAB9AALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL10640839 | 0.80 | NPC1 (0.55) | CPS1NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL10637691 | 0.80 | CPS1 (0.47) | CPS1NPC1RAB9AHSD11B1ALDH1A1 | |
| SCHEMBL10638084 | 0.80 | CPS1 (0.47) | CPS1NPC1RAB9AHSD11B1ALDH1A1 | |
| SCHEMBL4962237 | 0.79 | POLB (0.78) | NPC1RAB9APOLBHSD11B1ALDH1A1 | |
| SCHEMBL10638070 | 0.79 | CPS1 (0.57) | CPS1POLBHSD11B1ALDH1A1LMNA | |
| SCHEMBL14638260 | 0.78 | MGLL (0.66) | POLBHSD11B1ALDH1A1LMNAMGLL | |
| SCHEMBL11195650 | 0.77 | CPS1 (0.45) | CPS1NPC1RAB9AHSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4408053-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-10-04 | — | — | US | claimed |
| EP-0080104-B1 | 3-(4-PIPERIDYL)-1,2-BENZISOXAZOLES, PROCESS FOR THE PREPARATION THEREOF, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-12-14 | — | — | EP | disclosed |
| US-4528376-A | 3-(4-Piperidyl)-1,2-benzisoxazoles | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4469869-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1984-09-04 | — | — | US | disclosed |
| US-4408053-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4408054-A | ANALGESTICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-10-04 | — | — | US | disclosed |
| EP-0080104-A2 | 3-(4-Piperidyl)-1,2-benzisoxazoles, process for the preparation thereof, and a pharmaceutical composition comprising the same | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-06-01 | — | — | EP | disclosed |
| US-4355037-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1982-10-19 | — | — | US | disclosed |