MGLL — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL94863	0.86	17/20
SCHEMBL95324	1.00	16/20
SCHEMBL94891	0.64	16/20
SCHEMBL18713	1.00	15/20
SCHEMBL94095	0.57	15/20
SCHEMBL94730	1.00	14/20
SCHEMBL42947	0.60	14/20
SCHEMBL94319	0.60	14/20
SCHEMBL58050	1.00	12/20
SCHEMBL94040	0.54	12/20
SCHEMBL61934	0.52	12/20
SCHEMBL44144	0.59	11/20
SCHEMBL34594	0.56	11/20
SCHEMBL44044	0.54	11/20
Hydrochloric Acid (SCHEMBL44524)	0.52	11/20
SCHEMBL59456	0.83	10/20
SCHEMBL30710	0.62	10/20
SCHEMBL94429	0.52	10/20
SCHEMBL94147	0.46	10/20
SCHEMBL22910	0.80	9/20

Clinical trials — most relevant to MGLL by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons	PHASE4	COMPLETED
Visceral Adiposity and Diabetes: Translating Form to Function Using Imaging	PHASE4	COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Orlistat for the Treatment of Type I Hyperlipoproteinemia	PHASE2	COMPLETED
Human Models of Selective Insulin Resistance: Alpelisib, Part I	PHASE1	RECRUITING
CS-121 APOC3 Base Editing in FCS	EARLY_PHASE1	RECRUITING
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Lysosomal Acid Lipase (LAL) Deficiency Registry	nan	RECRUITING
Microbial Enzyme Impact on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Adults	nan	COMPLETED
Plasma Triglyceride Lipolysis in Multifactorial Chylomicronemia	nan	COMPLETED
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients	nan	COMPLETED
Orlistat Induced Modulation on the Fatty Acid Composition in Obese Females	nan	COMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans	nan	COMPLETED
Effect of Cryolipolysis on Insulin Resistance	nan	UNKNOWN
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism	nan	COMPLETED
Increased Inflammation-resolving Activity by Omega-3 Monoglycerides in Peripheral Blood Mononuclear Cells (PBMC).	nan	RECRUITING
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype	nan	COMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy	nan	NOT_YET_RECRUITING
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV	nan	NOT_YET_RECRUITING
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Kuwait Adult Diabetes Epidemiological Multidisciplinary (KADEM) Program	nan	RECRUITING
Fighting Fatty Liver in India	nan	UNKNOWN
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes	nan	COMPLETED
Effects of Lipids on Gastric Emptying, Satiety Hormones, and Appetite in Severe Overweight	nan	COMPLETED
Metabolic Actions of Omega-3 Fatty Acids	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MGLL binder may also engage these)

Protein	Name	Similarity
Q8R431	—	1.000	Q8R431 →
O35678	—	0.999	O35678 →
Q08C93	—	0.949	Q08C93 →
Q3UFF7	—	0.945	Q3UFF7 →
Q9Z2G9	—	0.945	Q9Z2G9 →
B0BNF8	—	0.945	B0BNF8 →
P50170	—	0.944	P50170 →
Q8HZJ0	—	0.944	Q8HZJ0 →
Q5H879	—	0.943	Q5H879 →
Q2KIJ5	—	0.943	Q2KIJ5 →
Q8CHS7	—	0.942	Q8CHS7 →
O75452	—	0.942	O75452 →
Q91WC3	—	0.942	Q91WC3 →
COMT	Catechol O-methyltransferase	0.942	landscape →
Q1RMJ5	—	0.942	Q1RMJ5 →
Q5R514	—	0.941	Q5R514 →
O88876	—	0.941	O88876 →
O75911	—	0.941	O75911 →
Q3T0R4	—	0.941	Q3T0R4 →
A3KCL7	—	0.941	A3KCL7 →
P13439	—	0.940	P13439 →
Q9CQL0	—	0.940	Q9CQL0 →
O77769	—	0.940	O77769 →
P22734	—	0.940	P22734 →
A1YFX9	—	0.940	A1YFX9 →
Q3ZBE9	—	0.940	Q3ZBE9 →
Q96NN9	—	0.940	Q96NN9 →
Q6AYR6	—	0.940	Q6AYR6 →
Q8R164	—	0.939	Q8R164 →
Q9BUP3	—	0.939	Q9BUP3 →