Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | PDE4A | P27815 | 19/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10638635 | 0.82 | PDE4A (0.58) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10638881 | 0.81 | PDE3B (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10632760 | 0.80 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10632604 | 0.78 | PDE3B (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10638580 | 0.78 | PDE3B (0.60) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10638692 | 0.76 | PDE3B (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10638878 | 0.76 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7416132 | 0.76 | PDE4A (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10876859 | 0.76 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Piroximone SCHEMBL119758 | 0.76 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0118790-B1 | NOVEL AROYLIMIDAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-07-06 | — | — | EP | claimed |
| EP-0118790-B1 | NOVEL AROYLIMIDAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4552880-A | Aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0118790-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-09-19 | — | — | EP | disclosed |