Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 4/20 | 1.00 |
| ▸ | PDE4A | P27815 | 17/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10864124 | 0.85 | PDE3B (0.74) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10876599 | 0.84 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7446222 | 0.84 | PDE3B (0.72) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10876292 | 0.84 | PDE3B (0.72) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9787143 | 0.83 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10632760 | 0.83 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7434193 | 0.82 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7441027 | 0.80 | PDE3B (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7430671 | 0.80 | PDE3B (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10635478 | 0.79 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196821-A2 | TARGETING NEUROPOD CELL GUCY2C TO CONTROL VISCERAL PAIN AND APPETITE | THOMAS JEFFERSON UNIVERSITY (US) | 2023-10-12 | — | — | WO | claimed |
| EP-3621593-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | Cardix Therapeutics LLC (US) | 2020-03-18 | — | — | EP | claimed |
| WO-2019194866-A1 | DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | Cardix Therapeutics LLC (US) | 2019-10-10 | — | — | WO | claimed |
| US-20190231786-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | CARDIX Therapeutics, LLC | 2019-08-01 | — | — | US | claimed |
| US-20190070184-A1 | DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | Cardix Therapeutics LLC (US) | 2019-03-07 | — | — | US | claimed |
| US-20180325907-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | CARDIX Therapeutics, LLC | 2018-11-15 | — | — | US | claimed |
| WO-2018208723-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | Cardix Therapeutics LLC (US) | 2018-11-15 | — | — | WO | claimed |
| US-10117869-B2 | PDE III inhibitors for treatment of asymptomatic heart failure | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2018-11-06 | — | — | US | claimed |
| EP-3210605-A1 | USE OF PDE III INHIBITORS FOR THE TREAMENT OF ASYMPTOMATIC (OCCULT) HEART FAILURE | Boehringer Ingelheim Vetmedica GmbH (DE) | 2017-08-30 | — | — | EP | claimed |
| US-9463199-B2 | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2016-10-11 | — | — | US | claimed |
| WO-2000012076-A1 | NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-03-09 | — | — | WO | claimed |
| EP-0961616-A1 | NON-HORMONAL METHOD OF CONTRACEPTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1999-12-08 | — | — | EP | claimed |
| WO-1999020223-A2 | LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE | NOVO NORDISK A/S (DK) | 1999-04-29 | — | — | WO | claimed |
| WO-1999014239-A1 | COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY | FORSSMANN WOLF GEORG (DE) | 1999-03-25 | — | — | WO | claimed |
| WO-1998010765-A1 | NON-HORMONAL METHOD OF CONTRACEPTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1998-03-19 | — | — | WO | claimed |
| US-4868182-A | HYPOTENSIVE AND CARDIOTONIC, SYNERGISTIC | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | claimed |
| EP-0268146-A1 | Enhancement of prazosin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-05-25 | — | — | EP | claimed |
| EP-0059948-B1 | NOVEL AROYLIMIDAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-11-13 | — | — | EP | claimed |
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | claimed |
| EP-0059948-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-09-15 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190070184-A1 | DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES | ADRB2, ADRA2C, ADRB1 | PDE3B 84/4885PDE3A 81/4885PDE4A 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.