Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8764455 | 0.89 | HMGCR (0.52) | HMGCRTSHRHPGDHSD17B10ALOX15 | |
| SCHEMBL16736863 | 0.89 | HMGCR (0.52) | HMGCRTSHRHSD17B10ALOX15ALOX12 | |
| SCHEMBL16736876 | 0.85 | HMGCR (0.48) | HMGCRHSD17B10ALOX15ALOX12ALOX5 | |
| SCHEMBL574286 | 0.85 | HMGCR (0.48) | HMGCRTSHRHPGDALOX15ALOX5 | |
| SCHEMBL10940941 | 0.84 | TSHR (0.48) | HMGCRTSHRHPGDHSD17B10ALOX15 | |
| SCHEMBL1760537 | 0.83 | HMGCR (0.64) | HMGCRTSHRHSD17B10ALOX15ALOX5 | |
| SCHEMBL16736725 | 0.82 | TYR (0.50) | HMGCRTSHRHPGDALOX15ALOX12 | |
| SCHEMBL16736776 | 0.82 | TYR (0.50) | HMGCRTSHRHPGDALOX15ALOX12 | |
| SCHEMBL13767807 | 0.81 | HPGD (0.48) | TSHRHPGDHSD17B10ALOX15ALOX12 | |
| SCHEMBL16736718 | 0.81 | HMGCR (0.44) | HMGCRALOX15ALOX12PTPN1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4764521-A | Leukotriene antagonists and a method of use there as | ELI LILLY AND COMPANY (US) | 1988-08-16 | — | — | US | disclosed |
| EP-0132367-B1 | LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1988-06-08 | — | — | EP | disclosed |
| EP-0118377-B1 | PROCESS FOR THE PRODUCTION OF METACHLORINATED PHENOLS | RHONE-POULENC CHIMIE (FR) | 1988-03-09 | — | — | EP | disclosed |
| EP-0132367-A2 | Leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1985-01-30 | — | — | EP | disclosed |
| EP-0118377-A2 | Process for the production of metachlorinated phenols | RHONE-POULENC CHIMIE (FR) | 1984-09-12 | — | — | EP | disclosed |
| EP-0055196-B1 | PROCESS FOR THE SYNTHESIS OF METACHLOROPHENOLS | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-04-18 | — | — | EP | disclosed |
| EP-0055198-B1 | PROCESS FOR THE SYNTHESIS OF METACHLOROPHENOLS | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-04-04 | — | — | EP | disclosed |
| EP-0055197-B1 | PROCESS FOR THE SYNTHESIS OF METACHLOROPHENOLS | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-04-04 | — | — | EP | disclosed |
| EP-0055196-A1 | Process for the synthesis of metachlorophenols | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1982-06-30 | — | — | EP | disclosed |
| EP-0055197-A1 | Process for the synthesis of metachlorophenols | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1982-06-30 | — | — | EP | disclosed |
| EP-0055198-A1 | Process for the synthesis of metachlorophenols | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1982-06-30 | — | — | EP | disclosed |