Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007660 | 0.94 | HTR2A (0.49) | KDM4EPOLBSMN1; SMN2HTR7HTR2A | |
| Oxalic Acid SCHEMBL10845371 | 0.92 | HTR2A (0.55) | HTR7HTR2ADRD2HTR6DRD4 | |
| Oxalic Acid SCHEMBL10637866 | 0.91 | KCNH2 (0.50) | HTR7HTR2ADRD2HTR6DRD4 | |
| Oxalic Acid SCHEMBL10850824 | 0.89 | DRD2 (0.52) | HTR7HTR2ADRD2HTR6DRD4 | |
| SCHEMBL11015087 | 0.86 | DRD2 (0.57) | HTR7HTR2ADRD2HTR6DRD4 | |
| SCHEMBL11010238 | 0.85 | KCNH2 (0.56) | HTR7HTR2ADRD2HTR6HTR1A | |
| SCHEMBL11013895 | 0.84 | DRD2 (0.54) | HTR7HTR2ADRD2HTR6DRD4 | |
| Oxalic Acid SCHEMBL10634863 | 0.83 | HTR2A (0.56) | HTR7HTR2ADRD2HTR6HTR1A | |
| Oxalic Acid SCHEMBL10637290 | 0.82 | DRD2 (0.56) | HTR7HTR2ADRD2HTR6HTR1A | |
| Oxalic Acid SCHEMBL10641125 | 0.81 | DRD2 (0.49) | HTR7HTR2ADRD2HTR6DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091511-B1 | 1-(3-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PROPYL)-4-(SUBSTITUTED)-PIPERAZINES AND -PIPERIDINES, A PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-05-11 | — | — | EP | disclosed |
| US-4610988-A | HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-09-09 | — | — | US | disclosed |
| US-4609658-A | ANTIPSYCHOTIC, ANALGESIC | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-09-02 | — | — | US | disclosed |
| US-4604395-A | NERVOUS SYSTEM DISORDERS, ANALGESICS, HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-08-05 | — | — | US | disclosed |
| US-4536578-A | ANTIHALLUCINOGENS, HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-08-20 | — | — | US | disclosed |