Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATF4 | P18848 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.39 |
| ▸ | RELA | Q04206 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847887 | 0.88 | POLB (0.48) | CYP4F2CYP4A11MEN1KMT2AATF4 | |
| SCHEMBL11471349 | 0.88 | CYP4F2 (0.44) | CYP4F2CYP4A11MEN1KMT2AATF4 | |
| SCHEMBL5847886 | 0.88 | POLB (0.48) | CYP4F2CYP4A11MEN1KMT2AATF4 | |
| SCHEMBL5847882 | 0.88 | POLB (0.48) | CYP4F2CYP4A11MEN1KMT2AATF4 | |
| Hydrochloric Acid SCHEMBL11471350 | 0.86 | POLB (0.47) | CYP4F2CYP4A11MEN1KMT2AATF4 | |
| SCHEMBL5839879 | 0.86 | ESR1 (0.56) | CYP4F2CYP4A11ESR1ESR2NFKB1 | |
| SCHEMBL24496756 | 0.85 | MEN1 (0.47) | CYP4F2CYP4A11MEN1KMT2AATF4 | |
| SCHEMBL23552434 | 0.84 | MEN1 (0.46) | CYP4F2CYP4A11MEN1KMT2AATF4 | |
| SCHEMBL4672067 | 0.83 | CYP4F2 (0.45) | CYP4F2CYP4A11ESR1ESR2SMN1; SMN2 | |
| SCHEMBL19520540 | 0.82 | CYP4F2 (0.52) | CYP4F2CYP4A11MEN1KMT2AATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020223538-A1 | SUBSTITUTED CYCLOALKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2020-11-05 | — | — | WO | disclosed |
| US-20130289086-A1 | Aminopyrrolidinone Derivatives and Uses Thereof | DUGGAN MARK E (US) | 2013-10-31 | — | — | US | disclosed |
| US-8252829-B2 | Aminopyrrolidinone derivatives and uses thereof | LINK MEDICINE CORPORATION (US) | 2012-08-28 | — | — | US | disclosed |
| EP-2438059-A1 | AMINOPYRROLIDINONE DERIVATIVES AND USES THEREOF | Link Medicine Corporation (US) | 2012-04-11 | — | — | EP | disclosed |
| US-20110021590-A1 | AMINOPYRROLIDINONE DERIVATIVES AND USES THEREOF | LINK MEDICINE CORPORATION (US) | 2011-01-27 | — | — | US | disclosed |
| WO-2010141932-A1 | AMINOPYRROLIDINONE DERIVATIVES AND USES THEREOF | LINK MEDICINE CORPORATION (US) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289086-A1 | Aminopyrrolidinone Derivatives and Uses Thereof | PRMT1, PRMT5, AGTR2 | CYP4F2 1415/4885CYP4A11 481/4885MEN1 1373/4885 |
| US-20110021590-A1 | AMINOPYRROLIDINONE DERIVATIVES AND USES THEREOF | PRMT1, PRMT5, AGTR2 | CYP4F2 1415/4885CYP4A11 481/4885MEN1 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.