AGTR2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL243199	1.00	20/20
SCHEMBL243788	1.00	20/20
SCHEMBL244431	1.00	20/20
SCHEMBL242832	0.75	20/20
SCHEMBL242893	0.68	20/20
Olodanrigan (SCHEMBL244657)	1.00	19/20
Olodanrigan (SCHEMBL421411)	1.00	19/20
SCHEMBL245015	0.94	19/20
SCHEMBL461335	0.54	19/20
SCHEMBL243579	1.00	18/20
SCHEMBL241232	0.88	18/20
Pratosartan (SCHEMBL93595)	0.73	17/20
SCHEMBL242222	1.00	16/20
SCHEMBL93596	0.71	16/20
SCHEMBL464339	0.51	16/20
SCHEMBL243845	0.62	15/20
SCHEMBL421422	0.56	15/20
SCHEMBL433767	0.56	15/20
SCHEMBL102109	0.62	14/20
Olmesartan Medoxomil (SCHEMBL16403)	1.00	12/20

Clinical trials — most relevant to AGTR2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Olmesartan on Angiotensin(1-7) Levels and Vascular Functions in Diabetes and Hypertension	PHASE4	COMPLETED
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension	PHASE4	COMPLETED
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism	PHASE4	COMPLETED
Telmisartan for Treatment of COVID-19 Patients	PHASE4	COMPLETED
Effects of Losartan on Insulin Resistance in Patients With Heart Failure	PHASE4	COMPLETED
Pharmacodynamic Influences of Candesartan, Atenolol, Hydrochlorothiazide and Drug Combinations in Hypertensive Patients.	PHASE4	COMPLETED
Direct Renin Inhibition Effects on Atherosclerotic Biomarkers	PHASE4	COMPLETED
Blood Pressure Regulation - Role of Potassium	PHASE4	COMPLETED
A Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension	PHASE3	COMPLETED
Efficacy and Safety Study of Azilsartan Medoxomil Compared to Ramipril for Treating Essential Hypertension	PHASE3	COMPLETED
The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function	PHASE3	COMPLETED
The Role of Angiotensin Type I Receptor in the Regulation of Human Coronary Vascular Function	PHASE3	COMPLETED
Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C	PHASE3	COMPLETED
Angiotensin II Antagonist in Severe Sepsis	PHASE3	UNKNOWN
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients	PHASE3	UNKNOWN
Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial	PHASE2/PHASE3	UNKNOWN
Efficacy and Safety of Azilsartan in Subjects With Essential Hypertension	PHASE2	COMPLETED
: Vascular Function in Health and Disease	PHASE1	RECRUITING
Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications	PHASE1	UNKNOWN
Expression and Function of the Renin-Angiotensin System in the Esophagus	EARLY_PHASE1	COMPLETED
Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker	nan	UNKNOWN
Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)	nan	COMPLETED
Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Risk of COVID_19	nan	UNKNOWN
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome	nan	UNKNOWN
Renin-Angiotensin System Inhibitors and COVID-19	nan	UNKNOWN
Long Term Effects of Enalapril and Losartan on Genetic Heart Disease	nan	COMPLETED
Residual Renal Function Preservation in Peritoneal Dialysis Patients	nan	UNKNOWN
Angiotensin II Antagonism of TGF-Beta 1	nan	COMPLETED
Clinical Study Evaluating the Effect of Losartan	nan	RECRUITING
Non-invasive Haemodynamic Assessment in Hypertension	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AGTR2 binder may also engage these)

Protein	Name	Similarity
P35374	—	1.000	P35374 →
Q9Z0Z6	—	1.000	Q9Z0Z6 →
Q28929	—	1.000	Q28929 →
P35351	—	1.000	P35351 →
P35373	—	0.998	P35373 →
P32303	—	0.996	P32303 →
O18982	—	0.996	O18982 →
P34976	—	0.995	P34976 →
P79785	—	0.995	P79785 →
P51676	—	0.995	P51676 →
P49685	—	0.994	P49685 →
P29089	—	0.994	P29089 →
O97663	—	0.994	O97663 →
P56491	—	0.992	P56491 →
P29754	—	0.992	P29754 →
Q0VDU3	—	0.991	Q0VDU3 →
P56412	—	0.991	P56412 →
CCR2	C-C chemokine receptor type 2	0.991	landscape →
P61072	—	0.991	P61072 →
Q7YS92	—	0.991	Q7YS92 →
Q28474	—	0.990	Q28474 →
Q9NPB9	—	0.990	Q9NPB9 →
Q61038	—	0.990	Q61038 →
P56482	—	0.989	P56482 →
Q3U507	—	0.989	Q3U507 →
O19024	—	0.989	O19024 →
A6QNL7	—	0.989	A6QNL7 →
Q9BG77	—	0.989	Q9BG77 →
P70658	—	0.988	P70658 →
O35210	—	0.988	O35210 →