Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655696 | 0.85 | NAMPT (0.43) | HTR1DHTR1BOPRM1SIGMAR1OPRD1 | |
| SCHEMBL9179579 | 0.81 | HRH3 (0.49) | HTR1DHTR1BHRH3OPRM1SIGMAR1 | |
| SCHEMBL156472 | 0.78 | OPRL1 (0.61) | OPRM1MC4ROPRD1OPRK1SLC6A4 | |
| SCHEMBL5520738 | 0.78 | JAK2 (0.50) | OPRD1OPRK1TSHRALOX15 | |
| SCHEMBL18081021 | 0.72 | OPRM1 (0.54) | OPRM1OPRD1OPRK1SLC6A4ADRA1A | |
| SCHEMBL10641408 | 0.72 | CD274 (0.45) | HTR1DHTR1BOPRM1SIGMAR1MC4R | |
| SCHEMBL17606451 | 0.72 | OPRL1 (0.58) | OPRM1SIGMAR1MC4ROPRL1TSHR | |
| SCHEMBL10516603 | 0.72 | SLC6A2 (0.31) | SLC6A4 | |
| SCHEMBL15681094 | 0.71 | OPRM1 (0.60) | MAOBOPRM1SIGMAR1MC4ROPRK1 | |
| SCHEMBL18986523 | 0.71 | KDM4E (0.48) | OPRM1SIGMAR1MC4ROPRL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295833-A1 | Aromatic-Spiropiperidine oxazepinones (and thiones) | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1988-12-21 | — | — | EP | disclosed |