Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649612 | 0.83 | CYP4F2 (0.48) | SMN1; SMN2CYP4F2CYP4A11MAPK1BAZ2B | |
| SCHEMBL10645317 | 0.82 | CYP4F2 (0.47) | SMN1; SMN2CYP4F2CYP4A11MAPK1BAZ2B | |
| SCHEMBL9706684 | 0.79 | MAPK1 (0.48) | SMN1; SMN2CYP4F2CYP4A11MAPK1BAZ2B | |
| SCHEMBL9706611 | 0.77 | KDM4E (0.46) | SMN1; SMN2CYP4F2CYP4A11MAPK1BAZ2B | |
| SCHEMBL10647208 | 0.77 | PARP1 (0.47) | SMN1; SMN2CYP4F2CYP4A11MAPK1HSD17B10 | |
| SCHEMBL10647288 | 0.76 | CYP4F2 (0.41) | SMN1; SMN2CYP4F2CYP4A11MAPK1BAZ2B | |
| SCHEMBL10650710 | 0.76 | BAZ2B (0.54) | SMN1; SMN2CYP4F2CYP4A11MAPK1BAZ2B | |
| SCHEMBL9587737 | 0.76 | BCAT1 (0.42) | SMN1; SMN2CYP4F2CYP4A11HSD17B10ALDH1A1 | |
| SCHEMBL6699195 | 0.74 | CYP4F2 (0.44) | SMN1; SMN2CYP4F2CYP4A11MAPK1BAZ2B | |
| SCHEMBL9587070 | 0.74 | MAPT (0.36) | SMN1; SMN2CYP4F2CYP4A11HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4760163-A | 3-(5-carboxy-4-substituted-phenyl)-(thio)uracil-esters and salts | HOFFMANN-LAROCHE INC. (US) | 1988-07-26 | — | — | US | disclosed |
| US-4746352-A | HERBICIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-05-24 | — | — | US | disclosed |