Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 7/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL448303 | 0.80 | HTT (0.50) | HTTL3MBTL1TSHRKDM4ETAAR1 | |
| SCHEMBL9369294 | 0.79 | CYP11B1 (0.55) | MAPT | |
| SCHEMBL8309874 | 0.75 | HTT (0.42) | HTTL3MBTL1TSHRKDM4ETAAR1 | |
| SCHEMBL3842559 | 0.74 | ALDH1A1 (0.45) | HTTL3MBTL1TSHRKDM4ETAAR1 | |
| SCHEMBL14204090 | 0.72 | HTT (0.40) | HTTL3MBTL1TSHRKDM4ETAAR1 | |
| SCHEMBL3120892 | 0.71 | CYP19A1 (0.53) | HTTL3MBTL1TSHRKDM4ETAAR1 | |
| SCHEMBL14833178 | 0.71 | CYP19A1 (0.53) | HTTL3MBTL1TSHRKDM4EDRD4 | |
| SCHEMBL4943132 | 0.70 | KDM4E (0.49) | HTTL3MBTL1TSHRKDM4EALDH1A1 | |
| SCHEMBL1037058 | 0.68 | HTT (0.66) | HTTTSHRKDM4EDRD4DRD3 | |
| SCHEMBL10648832 | 0.68 | HTT (0.43) | HTTL3MBTL1TSHRKDM4ETAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |