Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648208 | 0.91 | BRD4 (0.39) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10914095 | 0.88 | POLB (0.46) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10644333 | 0.87 | TRPM8 (0.43) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10645587 | 0.87 | TRPM8 (0.43) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10646822 | 0.87 | TRPM8 (0.43) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10647317 | 0.86 | POLB (0.42) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10647525 | 0.85 | SMN1; SMN2 (0.38) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL9691359 | 0.85 | POLB (0.44) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10651042 | 0.84 | BRD4 (0.41) | KDM4EGAAPOLBSMN1; SMN2NR1I2 | |
| SCHEMBL10647279 | 0.84 | NPC1 (0.43) | KDM4EGAAPOLBSMN1; SMN2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288758-A2 | Dihydropyridinamides, process for their preparation and their use in medicines | BAYER AG (DE) | 1988-11-02 | — | — | EP | disclosed |