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TRPM8

Transient receptor potential cation channel subfamily M member 8 · Q7Z2W7 · TRPM8 on Sugi Atlas →

113,489 patent compounds predicted against TRPM8, 63,318 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL117299 SCHEMBL117299 1.00 20/20
SCHEMBL117670 SCHEMBL117670 1.00 20/20
SCHEMBL117711 SCHEMBL117711 1.00 20/20
SCHEMBL118292 SCHEMBL118292 1.00 20/20
SCHEMBL118382 SCHEMBL118382 1.00 20/20
SCHEMBL118618 SCHEMBL118618 1.00 20/20
SCHEMBL118803 SCHEMBL118803 1.00 20/20
SCHEMBL118954 SCHEMBL118954 1.00 20/20
SCHEMBL118985 SCHEMBL118985 1.00 20/20
SCHEMBL119000 SCHEMBL119000 1.00 20/20
SCHEMBL119112 SCHEMBL119112 1.00 20/20
SCHEMBL119113 SCHEMBL119113 1.00 20/20
SCHEMBL119368 SCHEMBL119368 1.00 20/20
SCHEMBL119433 SCHEMBL119433 1.00 20/20
SCHEMBL119438 SCHEMBL119438 1.00 20/20
SCHEMBL119601 SCHEMBL119601 1.00 20/20
SCHEMBL119664 SCHEMBL119664 1.00 20/20
SCHEMBL119710 SCHEMBL119710 1.00 20/20
SCHEMBL119716 SCHEMBL119716 1.00 20/20
SCHEMBL119908 SCHEMBL119908 1.00 20/20

Clinical trials — most relevant to TRPM8 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra) PHASE4COMPLETED
Investigator Initiated Trial Using Dry Eye Surveys to Evaluate and Better Understand FDA Approved Acoltremon Treatment for Dry Eye Disease in Real World Treatment Settings (DESERT) PHASE4NOT_YET_RECRUITING
Switching From Restasis to TRYPTYR PHASE4NOT_YET_RECRUITING
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
TRPM8 Activators for Peripheral Neuropathy PHASE2ACTIVE_NOT_RECRUITING
Menthol for Improving Movement and Sleep in Parkinson's Disease Patients PHASE2NOT_YET_RECRUITING
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
Calcium Channel Blockade in Primary Aldosteronism PHASE2COMPLETED
The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer PHASE1RECRUITING
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor nanCOMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus nanCOMPLETED
Investigation of a New Human Model for Itch nanCOMPLETED
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients nanACTIVE_NOT_RECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
The Natural History of TRPV4 Neuropathy nanRECRUITING
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
Exploring the Effects of Magnesium Ions on Peripheral Neuropathy, Serum Magnesium Ion Concentration,Sleep Quality, and Quality of Life in Patients With Colorectal Cancer Receiving Chemotherapy. nanNOT_YET_RECRUITING
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TRPM8 binder may also engage these)

ProteinNameSimilarity
Q8R4D5 — 1.000 Q8R4D5 →
Q8R455 — 1.000 Q8R455 →
Q925B3 — 0.994 Q925B3 →
S5UH55 — 0.982 S5UH55 →
TRPM7 Transient receptor potential cation channel subfamily M member 7 0.981 landscape →
Q923J1 — 0.980 Q923J1 →
TRPM6 Transient receptor potential cation channel subfamily M member 6 0.977 landscape →
A0A0R4IMY7 — 0.976 A0A0R4IMY7 →
A8DZH4 — 0.971 A8DZH4 →
Q9BYT9 — 0.969 Q9BYT9 →
Q9LQV2 — 0.968 Q9LQV2 →
A2AHL1 — 0.968 A2AHL1 →
Q6R8G7 — 0.967 Q6R8G7 →
Q28204 — 0.967 Q28204 →
O18866 — 0.966 O18866 →
Q8CEF1 — 0.966 Q8CEF1 →
Q9H8M5 — 0.966 Q9H8M5 →
Q6NYU2 — 0.966 Q6NYU2 →
Q8CIR4 — 0.965 Q8CIR4 →
Q61143 — 0.965 Q61143 →
FEM1B Protein fem-1 homolog B 0.965 landscape →
Q7Z4N2 — 0.965 Q7Z4N2 →
O95427 — 0.964 O95427 →
Q8NHH9 — 0.964 Q8NHH9 →
Q5ZM55 — 0.964 Q5ZM55 →
Q9R032 — 0.963 Q9R032 →
Q9ER88 — 0.963 Q9ER88 →
Q9LNQ4 — 0.963 Q9LNQ4 →
Q8NHU2 — 0.963 Q8NHU2 →
Q6GPE5 — 0.963 Q6GPE5 →