Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.61 |
| ▸ | STING1 | Q86WV6 | 14/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tibenelast SCHEMBL449748 | 0.89 | STING1 (0.54) | GPR35STING1ALDH1A1HPGDTDP1 | |
| SCHEMBL10645446 | 0.89 | STING1 (0.49) | GPR35STING1CLK1HDAC3HDAC4 | |
| Tibenelast SCHEMBL10688452 | 0.88 | STING1 (0.53) | GPR35STING1ALDH1A1HPGDTDP1 | |
| Tibenelast SCHEMBL635433 | 0.88 | STING1 (0.53) | GPR35STING1ALDH1A1HPGDTDP1 | |
| SCHEMBL10641965 | 0.84 | STING1 (0.60) | STING1 | |
| SCHEMBL10642176 | 0.84 | STING1 (0.60) | STING1 | |
| SCHEMBL1608203 | 0.83 | GPR35 (0.67) | GPR35STING1HDAC3HDAC4HDAC1 | |
| SCHEMBL10537567 | 0.83 | STING1 (0.49) | GPR35STING1ALDH1A1HPGDTDP1 | |
| SCHEMBL10534791 | 0.83 | STING1 (0.49) | GPR35STING1ALDH1A1HPGDTDP1 | |
| SCHEMBL10642801 | 0.82 | STING1 (0.56) | GPR35STING1ALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139464-B1 | BENZOTHIOPHENE DERIVATES AS BRONCHODILATORS | ELI LILLY AND COMPANY (US) | 1988-10-19 | — | — | EP | disclosed |
| US-4552891-A | BRONCHODILATOR | ELI LILLY AND COMPANY (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0139464-A1 | Benzothiophene derivates as bronchodilators | ELI LILLY AND COMPANY (US) | 1985-05-02 | — | — | EP | disclosed |