GPR35

G-protein coupled receptor 35 · Q9HC97 · GPR35 on Sugi Atlas →

91,265 patent compounds predicted against GPR35, 55,723 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Lodoxamide (SCHEMBL119881)	1.00	13/20
Lodoxamide (SCHEMBL24175)	0.76	13/20
Trinitrophenol (SCHEMBL8744)	0.79	11/20
Trinitrophenol (SCHEMBL48279)	0.76	11/20
SCHEMBL69964	0.59	10/20
SCHEMBL69563	1.00	9/20
SCHEMBL70447	0.67	9/20
Dinoterb (SCHEMBL53794)	0.61	9/20
SCHEMBL68433	0.63	8/20
SCHEMBL118278	0.53	8/20
2,4-Dinitrophenol (SCHEMBL16980)	0.52	8/20
SCHEMBL45609	0.48	8/20
SCHEMBL103118	0.47	8/20
Dinitro Cresol (SCHEMBL20734)	1.00	7/20
Dinitro Cresol (SCHEMBL146050)	0.89	7/20
SCHEMBL69972	0.69	7/20
SCHEMBL103341	0.65	7/20
Dinoseb (SCHEMBL54664)	0.54	7/20
Dinitro Cresol (SCHEMBL43355)	0.69	6/20
3,5-Dinitrosalicylic Acid (SCHEMBL125292)	0.61	6/20

Clinical trials — most relevant to GPR35 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Phase 3 Clinical Study of Chiauranib Capsule in Patients With Small-cell Lung Cancer	PHASE3	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
An Investigation of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2245035 in Healthy Volunteers and Allergic Rhinitics.	PHASE1	COMPLETED
Evaluation of Two Radioactive Chemicals to Image mGluR5 Receptors in Brain	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People	EARLY_PHASE1	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Gastroparesis Registry 3	nan	COMPLETED
Gut Microbiota and Modulation of Liver Damage in NAFLD	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects	nan	COMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Colonic Delivery of DIM and Perilla Oil on Gut Hormones and Food Intake in Obesity	nan	COMPLETED
Effects of Ozanimod on Immune-mediated Mechanisms of Neurodegeneration in Multiple Sclerosis - a Preclinical Study	nan	UNKNOWN
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a GPR35 binder may also engage these)

Protein	Name	Similarity
Q9ES90	—	0.994	Q9ES90 →
Q76EI6	—	0.976	Q76EI6 →
LTB4R	Leukotriene B4 receptor 1	0.975	landscape →
Q8VCK6	—	0.973	Q8VCK6 →
FFAR2	Free fatty acid receptor 2	0.972	landscape →
Q99678	—	0.971	Q99678 →
Q3UFD7	—	0.971	Q3UFD7 →
O88855	—	0.970	O88855 →
Q8BYC4	—	0.970	Q8BYC4 →
FFAR3	Free fatty acid receptor 3	0.969	landscape →
Q9R0Q2	—	0.969	Q9R0Q2 →
Q3T181	—	0.967	Q3T181 →
Q8HZN9	—	0.967	Q8HZN9 →
Q8HZP1	—	0.967	Q8HZP1 →
O15529	—	0.966	O15529 →
Q8BUD0	—	0.966	Q8BUD0 →
P97583	—	0.965	P97583 →
B2GV46	—	0.965	B2GV46 →
GPR4	G-prodeshotein coupled receptor 4	0.964	landscape →
Q61125	—	0.964	Q61125 →
P48748	—	0.964	P48748 →
Q1JQB3	—	0.963	Q1JQB3 →
Q9BDQ5	—	0.963	Q9BDQ5 →
O46685	—	0.963	O46685 →
Q28642	—	0.962	Q28642 →
Q4KLH9	—	0.962	Q4KLH9 →
P50132	—	0.961	P50132 →
GPR68	G-protein coupled receptor 68	0.961	landscape →
Q5KSK8	—	0.961	Q5KSK8 →
Q9JJL9	—	0.960	Q9JJL9 →