Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.46 |
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | ADH5 | P11766 | 5/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10650257 | 0.80 | PDE3B (0.62) | PDE3BPDE3APDE2APRMT5WDR77 | |
| SCHEMBL10647436 | 0.79 | PDE3B (0.44) | PDE3BPDE3APDE2APRMT5WDR77 | |
| SCHEMBL11020105 | 0.79 | PDE3B (0.42) | PDE3BPDE3APDE2APRMT5WDR77 | |
| SCHEMBL11020107 | 0.79 | PDE3B (0.42) | PDE3BPDE3APDE2APRMT5WDR77 | |
| SCHEMBL10649130 | 0.78 | PDE3B (0.65) | PDE3BPDE3APDE2APRMT5WDR77 | |
| SCHEMBL10365557 | 0.78 | PDE3B (0.47) | PDE3BPDE3APDE2APDE4APDE4B | |
| Hydrochloric Acid SCHEMBL10366384 | 0.77 | PDE3B (0.47) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10363623 | 0.74 | PDE4A (0.44) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10364553 | 0.73 | PDE3B (0.44) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10365667 | 0.73 | PDE4A (0.38) | PDE3BPDE3APDE2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |