Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648603 | 0.80 | PDE3B (0.46) | PDE3BPDE3APDE2ACRBNTBXAS1 | |
| SCHEMBL10649130 | 0.78 | PDE3B (0.65) | PDE3BPDE3APDE2ACRBNTBXAS1 | |
| SCHEMBL11016212 | 0.78 | PDE3B (0.50) | PDE3BPDE3APDE2ACRBNTBXAS1 | |
| SCHEMBL11016210 | 0.78 | PDE3B (0.50) | PDE3BPDE3APDE2ACRBNTBXAS1 | |
| SCHEMBL10648271 | 0.77 | PDE3A (0.59) | PDE3BPDE3APDE2ACRBNTBXAS1 | |
| SCHEMBL7280366 | 0.77 | PDE3B (1.00) | PDE3BPDE3APDE2ACYP3A4LMNA | |
| SCHEMBL10648091 | 0.77 | PDE3B (0.43) | PDE3BPDE3ATBXAS1CYP3A4MAPT | |
| SCHEMBL7287713 | 0.75 | PDE3B (0.71) | PDE3BPDE3APDE2ACRBNTBXAS1 | |
| SCHEMBL10365556 | 0.75 | PDE3B (0.45) | PDE3BPDE3APDE2AIDO1CYP3A4 | |
| Hydrochloric Acid SCHEMBL10364633 | 0.74 | PDE3B (0.44) | PDE3BPDE3APDE2AIDO1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |