Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.73 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12933547 | 0.84 | HDAC1 (0.80) | HDAC1HDAC2NR1H4 | |
| SCHEMBL1079414 | 0.84 | HDAC1 (1.00) | HDAC1HDAC2NR1H4 | |
| SCHEMBL1067926 | 0.83 | HDAC1 (0.80) | HDAC1HDAC2NR1H4 | |
| SCHEMBL1064557 | 0.83 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL4533322 | 0.80 | ALDH1A1 (0.52) | HDAC1HDAC2NR1H4MAPTNPSR1 | |
| SCHEMBL2474525 | 0.80 | HDAC1 (0.51) | HDAC1HDAC2NR1H4MAPT | |
| SCHEMBL2503525 | 0.80 | NR1H4 (0.48) | HDAC1HDAC2NR1H4MAPT | |
| SCHEMBL30091837 | 0.80 | HDAC1 (0.62) | HDAC1HDAC2 | |
| SCHEMBL2734093 | 0.79 | HDAC1 (0.68) | HDAC1HDAC2 | |
| SCHEMBL2499264 | 0.79 | HDAC1 (0.59) | HDAC1HDAC2NR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-20050288282-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2005-12-29 | — | — | US | disclosed |
| EP-1590340-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2005-11-02 | — | — | EP | disclosed |
| US-6897220-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2005-05-24 | — | — | US | disclosed |
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| US-20040106599-A1 | Inhibitors of histone deacetylase | 92229129 QUEBEC INC. (CA) | 2004-06-03 | — | — | US | disclosed |
| WO-2004005513-A2 | METHODS FOR SPECIFICALLY INHIBITING HISTONE DEACETYLASE-7 AND 8 | METHYLGENE, INC. (CA) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288282-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885HDAC2 5/4885NR1H4 1465/4885 |
| US-20040106599-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885HDAC2 5/4885NR1H4 1465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.