Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153234 | 0.81 | KMT2A (0.58) | KMT2AKDM4EMAPTRXFP1HSD17B10 | |
| SCHEMBL1443100 | 0.81 | GAA (0.53) | KMT2AKDM4EMAPTTYK2SYK | |
| SCHEMBL3170376 | 0.81 | KMT2A (0.68) | KMT2AKDM4EMAPTRXFP1HSD17B10 | |
| SCHEMBL1442249 | 0.79 | KMT2A (0.59) | KMT2AKDM4EMAPTTYK2SYK | |
| SCHEMBL13119696 | 0.79 | KMT2A (0.70) | KMT2AKDM4EMAPTRXFP1HSD17B10 | |
| SCHEMBL1025786 | 0.78 | KMT2A (1.00) | KMT2AKDM4EMAPTRXFP1HSD17B10 | |
| SCHEMBL7120320 | 0.77 | KMT2A (0.53) | KMT2AKDM4EMAPTRXFP1HSD17B10 | |
| SCHEMBL2207007 | 0.76 | KMT2A (0.55) | KMT2AKDM4EMAPTRXFP1CRHBP | |
| SCHEMBL15008988 | 0.76 | KMT2A (0.49) | KMT2AKDM4EMAPTRXFP1HSD17B10 | |
| SCHEMBL19687232 | 0.76 | KMT2A (0.51) | KMT2AKDM4EMAPTRXFP1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0121341-B1 | TRIAZOLO(4,3-C)PYRIMIDINES AND TRIAZOLO(1,5-C)PYRIMIDINES SUBSTITUTED BY NITROGEN-CONTAINING HETEROCYCLIC RINGS | RIKER LABORATORIES, INCORPORATED (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4572910-A | BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1986-02-25 | — | — | US | disclosed |
| US-4536579-A | BRONCHODILATING AGENTS | RIKER LABORATORIES, INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4477450-A | BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1984-10-16 | — | — | US | disclosed |
| EP-0121341-A1 | Triazolo(4,3-c)pyrimidines and triazolo(1,5-c)pyrimidines substituted by nitrogen-containing heterocyclic rings | RIKER LABORATORIES, INCORPORATED (US) | 1984-10-10 | — | — | EP | disclosed |