Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10830610 | 0.84 | HRH4 (0.53) | KMT2ACRHBPCRHR2KDM4EMAPT | |
| SCHEMBL10830350 | 0.83 | HRH4 (0.66) | KDM4EMAPTRXFP1HRH4HRH3 | |
| SCHEMBL13119696 | 0.83 | KMT2A (0.70) | KMT2ACRHBPCRHR2KDM4EMAPT | |
| SCHEMBL1025786 | 0.81 | KMT2A (1.00) | KMT2ACRHBPCRHR2KDM4EMAPT | |
| SCHEMBL10831377 | 0.81 | MAPT (0.48) | KMT2ACRHBPCRHR2KDM4EMAPT | |
| SCHEMBL10650101 | 0.81 | KMT2A (0.63) | KMT2ACRHBPCRHR2KDM4EMAPT | |
| SCHEMBL2814649 | 0.80 | KMT2A (0.49) | KMT2ACRHBPCRHR2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3281511 | 0.79 | KDM4E (0.46) | KMT2AKDM4EMAPTRXFP1CYP1A2 | |
| SCHEMBL1123929 | 0.79 | KMT2A (0.65) | KMT2ACRHBPCRHR2KDM4EMAPT | |
| SCHEMBL794010 | 0.79 | CRHBP (0.61) | KMT2ACRHBPCRHR2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604601-B1 | HETERO RING COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| EP-2604601-A1 | HETERO RING COMPOUND | Astellas Pharma Inc. (JP) | 2013-06-19 | — | — | EP | disclosed |
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-13 | — | — | US | disclosed |
| CN-103025725-A | Heterocyclic compounds | ASTELLAS PHARMA INC | 2013-04-03 | — | — | CN | disclosed |
| US-20100009987-A1 | AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK | MERCK SHARP & DOHME LIMITED (GB) | 2010-01-14 | — | — | US | disclosed |
| US-20100009987-A1 | AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK | MERCK SHARP & DOHME LIMITED (GB) | 2010-01-14 | — | — | US | disclosed |
| US-20100009987-A1 | AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK | MERCK SHARP & DOHME LIMITED (GB) | 2010-01-14 | — | — | US | disclosed |
| EP-2032138-A2 | AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK | Merck Sharp & Dohme Limited (GB) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007141571-A2 | AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK | MERCK SHARP & DOHME LIMITED (GB) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007141571-A2 | AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK | MERCK SHARP & DOHME LIMITED (GB) | 2007-12-13 | — | — | WO | disclosed |
| EP-0582261-A1 | Cephalosporin compounds and processes for the preparation thereof | LUCKY LTD. (KR) | 1994-02-09 | — | — | EP | disclosed |
| US-4565864-A | INTERMEDIATES FOR BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1986-01-21 | — | — | US | disclosed |
| US-4503050-A | BRONCHODILATORS | RIKER LABORATORIES, INC. (US) | 1985-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009987-A1 | AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK | MAPT, MARK4, MARK3 | KMT2A 610/4885CRHBP 3034/4885CRHR2 4300/4885 |
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | IL2, NFATC1, ICOS | KMT2A 1663/4885CRHBP 3992/4885CRHR2 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.