Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.48 |
| ▸ | ADH5 | P11766 | 7/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647455 | 0.83 | TBXAS1 (0.37) | TBXAS1ADH5CYP3A4BAZ2BENPP2 | |
| SCHEMBL10645502 | 0.80 | STING1 (0.39) | TBXAS1ADH5CYP3A4BAZ2BHTT | |
| SCHEMBL10648270 | 0.78 | TBXAS1 (0.40) | TBXAS1ADH5CYP3A4BAZ2BTDP1 | |
| SCHEMBL11015693 | 0.77 | TBXAS1 (0.44) | TBXAS1ADH5EGLN3CYP3A4BAZ2B | |
| SCHEMBL11015694 | 0.77 | TBXAS1 (0.44) | TBXAS1ADH5EGLN3CYP3A4BAZ2B | |
| SCHEMBL10724330 | 0.76 | TBXAS1 (0.54) | TBXAS1EGLN3CYP3A4 | |
| SCHEMBL10645714 | 0.75 | CYP3A4 (0.36) | TBXAS1ADH5CYP3A4BAZ2BTDP1 | |
| SCHEMBL10622131 | 0.74 | TBXAS1 (0.63) | TBXAS1ADH5CYP3A4BAZ2BENPP2 | |
| SCHEMBL10729453 | 0.74 | TBXAS1 (0.46) | TBXAS1ADH5EGLN3CYP3A4BAZ2B | |
| SCHEMBL10663235 | 0.73 | IDO1 (0.52) | TBXAS1ADH5CYP3A4BAZ2BIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |