SCHEMBL10651561

SCHEMBL10651561

COC(=O)C1=C(C)N(O)C(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 1/20 0.65
NR3C1 P04150 1/20 0.65
ABCB1 P08183 1/20 0.65
ADORA3 P0DMS8 1/20 0.65
TBXA2R P21731 1/20 0.65
AGTR1 P30556 1/20 0.65
CCKBR P32239 1/20 0.65
PTGS2 P35354 1/20 0.65
PDE4D Q08499 1/20 0.65
SCN5A Q14524 1/20 0.65
SLC29A1 Q99808 1/20 0.65
CYP1A2 P05177 5/20 0.60
CYP3A4 P08684 5/20 0.60
CYP2C9 P11712 5/20 0.60
CYP2C19 P33261 5/20 0.60
LMNA P02545 4/20 0.60
MEN1 O00255 4/20 0.60
KMT2A Q03164 4/20 0.60
MAPT P10636 4/20 0.60
CYP2D6 P10635 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10652739 0.93 CYP1A2 (0.66) NR1I2NR3C1ABCB1ADORA3TBXA2R
SCHEMBL11802487 0.91 NR1I2 (0.65) NR1I2NR3C1ABCB1ADORA3TBXA2R
SCHEMBL10652546 0.89 CACNA1F (0.67) ADORA3CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL10652750 0.89 MAPT (0.61) NR1I2NR3C1ABCB1ADORA3TBXA2R
SCHEMBL10655363 0.88 CYP1A2 (0.63) ADORA3CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL10651557 0.87 CYP1A2 (0.76) ADORA3CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL30357961 0.86 ADORA3 (0.81) NR1I2NR3C1ABCB1ADORA3TBXA2R
SCHEMBL7159699 0.86 ADORA3 (0.81) NR1I2NR3C1ABCB1ADORA3TBXA2R
SCHEMBL9555199 0.85 CYP1A2 (0.60) NR1I2NR3C1ABCB1ADORA3TBXA2R
SCHEMBL10654578 0.85 CYP1A2 (0.62) ADORA3CYP1A2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0093945-B1 1,4-DIHYDROPYRIDINE DERIVATIVES KYOWA HAKKO KOGYO CO., LTD. (JP) 1988-11-23 EP claimed
US-4495192-A HYPOTENSIVE AGENTS; VASODILATORS KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-01-22 US claimed
EP-0093945-A2 1,4-Dihydropyridine derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1983-11-16 EP claimed
EP-0093945-B1 1,4-DIHYDROPYRIDINE DERIVATIVES KYOWA HAKKO KOGYO CO., LTD. (JP) 1988-11-23 EP disclosed
US-4495192-A HYPOTENSIVE AGENTS; VASODILATORS KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-01-22 US disclosed
EP-0093945-A2 1,4-Dihydropyridine derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1983-11-16 EP disclosed