SCHEMBL10652128

SCHEMBL10652128

CC1(C)C(=O)N(c2ccc(N=C=O)cc2)C1=O

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ELANE P08246 8/20 0.55
CYP3A4 P08684 2/20 0.41
TSHR P16473 1/20 0.41
TRPA1 O75762 1/20 0.37
PGR P06401 6/20 0.36
MAPK1 P28482 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CYP1A2 P05177 1/20 0.35
POLB P06746 1/20 0.33
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
F2 P00734 1/20 0.31
CTSG P08311 1/20 0.31
CMA1 P23946 1/20 0.31
CTRC Q99895 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12510891 0.91 CYP3A4 (0.59) ELANECYP3A4TSHRTRPA1PGR
SCHEMBL10652094 0.77 ELANE (0.55) ELANECYP3A4TSHRPGRSMN1; SMN2
SCHEMBL7463346 0.76 CYP3A4 (0.42) ELANECYP3A4TSHRTRPA1MAPK1
SCHEMBL10647506 0.76 CYP3A4 (0.50) ELANECYP3A4TSHRTRPA1PGR
SCHEMBL10645138 0.76 CYP3A4 (0.50) ELANECYP3A4TSHRTRPA1MAPK1
SCHEMBL42947 0.76 MGLL (0.60) CYP3A4TSHRMAPK1TDP1
SCHEMBL10653726 0.75 ELANE (0.63) ELANECYP3A4TSHRPGRSMN1; SMN2
SCHEMBL10645395 0.71 CYP3A4 (0.41) CYP3A4TSHRTRPA1MAPK1TDP1
SCHEMBL17208878 0.71 F2 (0.40) ELANECYP3A4TSHRTRPA1MAPK1
SCHEMBL16656343 0.71 CYP3A4 (0.48) CYP3A4TSHRTRPA1MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0181513-B1 AZETIDINEDIONE COMPOUNDS AS CROSSLINKERS FOR ELECTRODEPOSITED COATINGS THE DOW CHEMICAL COMPANY (US) 1988-06-22 EP disclosed
US-4721768-A Azetidinedione-monocarbonamide capped prepolymer THE DOW CHEMICAL COMPANY (US) 1988-01-26 US disclosed
US-4683302-A ON AUTOMOTIVE PARTS AND HOUSEHOLD APPLIANCES THE DOW CHEMICAL COMPANY (US) 1987-07-28 US disclosed
US-4668756-A POLYLACTAM BLOCK POLYMERS THE DOW CHEMICAL COMPANY (US) 1987-05-26 US disclosed
US-4642342-A Azetidinedione urethanes THE DOW CHEMICAL COMPANY (US) 1987-02-10 US disclosed
US-4612374-A Tris-azetidinedione derivative 1,3,5-triazin-2,4,6-triones THE DOW CHEMICAL COMPANY (US) 1986-09-16 US disclosed
US-4612098-A Process for electrodeposition using azetidinedione compounds as crosslinkers THE DOW CHEMICAL COMPANY (US) 1986-09-16 US disclosed
EP-0181513-A2 Azetidinedione compounds as crosslinkers for electrodeposited coatings THE DOW CHEMICAL COMPANY (US) 1986-05-21 EP disclosed
US-4576747-A Isocyanato-azetidinediones THE UPJOHN COMPANY (US) 1986-03-18 US disclosed
US-4576980-A CATHODES, CORROSION RESISTANCE THE DOW CHEMICAL COMPANY (US) 1986-03-18 US disclosed