Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 14/20 | 0.78 |
| ▸ | GFER | P55789 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6704755 | 0.88 | DHFR (0.74) | DHFRGFERMAPTGAAALDH1A1 | |
| SCHEMBL6700884 | 0.88 | DHFR (1.00) | DHFRGFERMAPT | |
| Hydrochloric Acid SCHEMBL10651989 | 0.86 | DHFR (0.97) | DHFRGFERMAPT | |
| SCHEMBL6701531 | 0.84 | DHFR (0.68) | DHFRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6701535 | 0.84 | DHFR (0.68) | DHFRMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6700402 | 0.84 | DHFR (0.68) | DHFRKDM4EADRA2CTP53 | |
| SCHEMBL6699085 | 0.84 | DHFR (0.72) | DHFRKDM4EALDH1A1USP2HSD17B10 | |
| SCHEMBL10650892 | 0.84 | DHFR (0.68) | DHFRMAPTSMN1; SMN2 | |
| SCHEMBL8167418 | 0.83 | DHFR (0.67) | DHFR | |
| SCHEMBL6696389 | 0.83 | DHFR (0.67) | DHFRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103464-B1 | DIAMINOPYRIMIDINES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-11-17 | — | — | EP | claimed |