Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4272933 | 0.77 | POLB (0.66) | POLBCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL29450270 | 0.77 | POLB (0.70) | POLBCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL9694998 | 0.77 | POLB (0.70) | POLBCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL19608972 | 0.75 | ADORA2A (0.56) | POLBADORA2ACYP1A2CYP2D6CLK4 | |
| SCHEMBL3731388 | 0.74 | ALDH1A1 (0.50) | POLBADORA2ACYP1A2CYP2D6CLK4 | |
| Hydrochloric Acid SCHEMBL10648998 | 0.73 | TOP2A (0.52) | — | |
| SCHEMBL31061121 | 0.72 | CYP1A2 (0.63) | POLBADORA2ACYP1A2CYP2D6CLK4 | |
| SCHEMBL23145043 | 0.72 | POLB (0.63) | POLBADORA2ACYP1A2CYP3A4MAPK1 | |
| SCHEMBL1408391 | 0.72 | POLB (1.00) | POLBMAPK1HSD17B10TSHRLMNA | |
| SCHEMBL5457232 | 0.72 | ALDH1A1 (0.44) | POLBADORA2ACYP1A2MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0093521-B1 | QUINOLINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-08-24 | — | — | EP | disclosed |
| US-4607039-A | 2-(AMINO-ALKYL-THIO OR -OXY) SUBSTITUTED | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-08-19 | — | — | US | disclosed |
| EP-0093521-A2 | Quinoline derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-11-09 | — | — | EP | disclosed |