Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 14/20 | 0.72 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.72 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.72 |
| ▸ | HTR2C | P28335 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656335 | 0.88 | CHRM3 (0.75) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10651021 | 0.85 | CHRM3 (0.75) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10651321 | 0.85 | CHRM3 (0.97) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10653812 | 0.84 | CHRM3 (1.00) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10655619 | 0.77 | CHRM3 (0.60) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10651354 | 0.77 | CHRM3 (0.97) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10654976 | 0.77 | CHRM3 (0.82) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10654776 | 0.76 | CHRM3 (0.97) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10651499 | 0.76 | CHRM3 (0.84) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10656906 | 0.75 | CHRM3 (1.00) | CHRM3CHRM5CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126654-B1 | TETRAHYDROISOXAZOLO(4,5-C)PYRIDINE DERIVATIVES AND PREPARATION THEREOF | H. LUNDBECK A/S (DK) | 1988-05-04 | — | — | EP | disclosed |
| US-4608378-A | Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems | H. LUNDBECK A/S (DK) | 1986-08-26 | — | — | US | disclosed |